Abdominal Aortic Aneurysm Clinical Trial
— AARDVARKOfficial title:
An Evaluation of the Effect of an Angiotensin-converting Enzyme (ACE) Inhibitor on the Growth Rate of Small Abdominal Aortic Aneurysms.
Verified date | January 2021 |
Source | Imperial College London |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Abdominal aortic aneurysms (AAA) are balloon-like swellings of the body's main blood vessel (aorta) as it courses through the abdomen. As a result of the National Aneurysm Screening programme many more of these will be detected. Small AAAs grow slowly and remain a benign condition until the diameter exceeds 2-3 times the diameter of the normal aorta (about 5.5cm in size), when operative repair of the aneurysm is recommended avoiding the potentially fatal event of bursting and bleeding (aneurysm rupture). It is therefore important to identify a strategy to prevent aneurysm growth. There is a suggestion that the use of a specific drug class, angiotensin converting enzyme (ACE) inhibitors, may reduce the risk of rupture of the larger aneurysms. This trial will assess whether an ACE inhibitor (perindopril) has aneurysm-related benefits, in patients with small AAAs at screening centres in the London area. The effects of perindopril versus a placebo(dummy) on AAA growth rates will be compared. In addition by comparing the effects of perindopril with the effects of equivalent blood pressure lowering with another non-ACE inhibitor class of drug (amlodipine) on aneurysm growth rate, we can see whether any benefits of perindopril are simply the result of lowering blood pressure. 225 Patients will be assigned to one of these 3 treatments by chance (randomisation).In addition to analysis of the effect of perindopril and blood pressure lowering,the effect of the treatments on quality of life will be assessed. Patients will return at 3-monthly intervals for an ultrasound scan and blood pressure measurements, with questionnaires regarding quality of life at the start and end of the 2-year research period. An ultrasound scan is a painless test that uses sound waves to create images of organs and structures inside your body.
Status | Completed |
Enrollment | 224 |
Est. completion date | April 2015 |
Est. primary completion date | April 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 55 Years and older |
Eligibility | Inclusion criteria: Willing and able to give written informed consent Men or women, aged at least 55 years With AAA 3 to 5.4 cm in diameter by internal or external measurement according to ultrasound A systolic BP <150mmHg (unless they require and are already receiving an ACE-inhibitor or amlodipine 10mg daily). Exclusion criteria: Patients who are already required to take either an ACE-inhibitor or a calcium channel blocker or Angiotensin II blocker (ARB) who cannot be converted to diuretic therapy and/ora 5mg dose of amlodipine for control (ie SBP < 150mmHg) of their BP. Those with known renal artery stenosis (>50%), or with a serum creatinine of >180µmol/L Those unable to give informed consent Those too frail to travel for 3-monthly surveillance will be excluded Any clinically significant medical condition which, in the opinion of the investigator, may interfere with the study results and or reduce life expectancy to < 2 years Participation in another trial of an investigational product or device within the previous 30 days Known allergy or sensitivity to perindopril or amlodipine Unable or unwilling to comply with the requirements of the study, in the opinion of the investigator. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust | Bournemouth | |
United Kingdom | Colchester Hospital | Colchester | |
United Kingdom | University Hospital Coventry and Warwickshire | Coventry | |
United Kingdom | Hull Royal Infirmary | Hull | |
United Kingdom | Charing Cross Hospital, Imperial College NHS Trust | London | |
United Kingdom | Royal Free Hospital | London | |
United Kingdom | St Mary's Hospital, Imperial College Healthcare NHS Trust | London | |
United Kingdom | St Thomas' Hospital | London | |
United Kingdom | Freeman Hospital | Newcastle |
Lead Sponsor | Collaborator |
---|---|
Imperial College London | National Institute for Health Research, United Kingdom |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the Growth Rate of Abdominal Aortic Aneurysm | Aneurysm growth rate over 2 years, estimated from the sequential AAA diameter measurements (external diameter measured in the longitudinal plane). | Annual rate over the entire period of 24 month | |
Secondary | Number of Participants With Aneurysm Related Death | 24 months |
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