1- Women Clinical Trial
Official title:
Epidemiology of Papillomavirus Infection (HPV) on Infected Women by Human Immunodeficience Virus (HIV) in West Indies and French Guiana.
Cervical cancer is a public health problem. In term of frequency and mortality, it
represents in Martinique the third localization the most frequently diagnosed and the fifth
cause of death by cancer. Cervical cancer is recognized as viro-inducted. Human
papillomavirus (HPV) is the etiologic agent, as a necessary but not sufficient cause, in the
cancer genesis. It is estimated than about 70 to 80% of women have been or will be infected
with an HPV in their genital life, the risks factors being those of the others sexually
transmitted diseases (STD). Most of HPV infection are transient, by spontaneous clearance in
a few months of the virus under episomal form.
Carcinogen risk is related to viral persistency which inducts the condition of cellular
transformation.
Infection persistency and subsequent carcinogen risk depend of the genotype concerned and of
the host immunitary response.
HIV infection is known to be associated with an higher prevalency of one or several
infection with HPV-HR.
However, no data about HIV/HPV coinfection prevalency are available nowadays in French
overseas department of South America whereas they are the most affected by HIV.
n/a
Observational Model: Cohort, Time Perspective: Prospective