Venous Thromboembolism — Mortality Due to Malignancy in Patients With Idiopathic Venous Thromboembolism
Citation(s)
Aderka D, Brown A, Zelikovski A, Pinkhas J Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer. Cancer. 1986 May 1;57(9):1846-9.
Ahmed Z, Mohyuddin Z Deep vein thrombosis as a predictor of cancer. Angiology. 1996 Mar;47(3):261-5.
Beckers MM, Verzijlbergen JF, van Buul MM, Prins MH, Biesma DH The potential role of positron emission tomography in the detection of occult cancer in 25 patients with venous thromboembolism. Ann Oncol. 2008 Jun;19(6):1203-4. doi: 10.1093/annonc/mdn156. Epub 2008 Apr 2.
Cornuz J, Pearson SD, Creager MA, Cook EF, Goldman L Importance of findings on the initial evaluation for cancer in patients with symptomatic idiopathic deep venous thrombosis. Ann Intern Med. 1996 Nov 15;125(10):785-93.
Girolami A, Prandoni P, Zanon E, Bagatella P, Girolami B Venous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs. Blood Coagul Fibrinolysis. 1999 Dec;10(8):455-7.
Piccioli A, Prandoni P Screening for occult cancer in patients with idiopathic venous thromboembolism: yes. J Thromb Haemost. 2003 Nov;1(11):2271-2.
PIOPED Investigators Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990 May 23-30;263(20):2753-9.
Sannella NA, O'Connor DJ Jr "Idiopathic" deep venous thrombosis: the value of routine abdominal and pelvic computed tomographic scanning. Ann Vasc Surg. 1991 May;5(3):218-22.
Subirà M, Mateo J, Souto JC, Altés A, Fontcuberta J Lack of association between venous thrombosis and subsequent malignancy in a retrospective cohort study in young patients. Am J Hematol. 1999 Mar;60(3):181-4.
Trousseau Studie, Mortaliteit Door Maligniteit Bij patiënten Met Idiopatische Veneuze Tromboembolie
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
