Clinical trial NCT02721719 - References

Ulcerative Colitis — The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis

Citation(s)

•   Abramson O, Qiu S, Erle DJ
  Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7. Immunology. 2001 Jun;103(2):155-63. doi: 10.1046/j.0019-2805.2001.01234.x.
•   Assi K, Patterson S, Dedhar S, Owen D, Levings M, Salh B
  Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire. BMC Immunol. 2011 Aug 1;12:42. doi: 10.1186/1471-2172-12-42.
•   Baaten BJ, Cooper AM, Swain SL, Bradley LM
  Location, location, location: the impact of migratory heterogeneity on T cell function. Front Immunol. 2013 Oct 8;4:311. doi: 10.3389/fimmu.2013.00311.
•   Bakdash G, Vogelpoel LT, van Capel TM, Kapsenberg ML, de Jong EC
  Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. Mucosal Immunol. 2015 Mar;8(2):265-78. doi: 10.1038/mi.2014.64. Epub 2014 Jul 16.
•   Bridges LC, Sheppard D, Bowditch RD
  ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J. 2005 Apr 1;387(Pt 1):101-8. doi: 10.1042/BJ20041444.
•   Briskin M, Winsor-Hines D, Shyjan A, Cochran N, Bloom S, Wilson J, McEvoy LM, Butcher EC, Kassam N, Mackay CR, Newman W, Ringler DJ
  Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol. 1997 Jul;151(1):97-110.
•   Cohen CJ, Crome SQ, MacDonald KG, Dai EL, Mager DL, Levings MK
  Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. J Immunol. 2011 Dec 1;187(11):5615-26. doi: 10.4049/jimmunol.1101058. Epub 2011 Nov 2.
•   Cooper MA, Fehniger TA, Caligiuri MA
  The biology of human natural killer-cell subsets. Trends Immunol. 2001 Nov;22(11):633-40. doi: 10.1016/s1471-4906(01)02060-9.
•   Denucci CC, Mitchell JS, Shimizu Y
  Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there. Crit Rev Immunol. 2009;29(2):87-109. doi: 10.1615/critrevimmunol.v29.i2.10.
•   El Azreq MA, Boisvert M, Cesaro A, Page N, Loubaki L, Allaeys I, Chakir J, Poubelle PE, Tessier PA, Aoudjit F
  alpha2beta1 integrin regulates Th17 cell activity and its neutralization decreases the severity of collagen-induced arthritis. J Immunol. 2013 Dec 15;191(12):5941-50. doi: 10.4049/jimmunol.1301940. Epub 2013 Nov 15.
•   Han JM, Patterson SJ, Levings MK
  The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol. 2012 Aug 13;3:245. doi: 10.3389/fimmu.2012.00245. eCollection 2012.
•   Hardenberg G, Steiner TS, Levings MK
  Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol. 2011 Apr;23(2):130-8. doi: 10.1016/j.smim.2011.01.012. Epub 2011 Feb 3.
•   Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK
  Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol. 2013 Mar 1;190(5):2001-8. doi: 10.4049/jimmunol.1201379. Epub 2013 Jan 28.
•   Hovhannisyan Z, Treatman J, Littman DR, Mayer L
  Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011 Mar;140(3):957-65. doi: 10.1053/j.gastro.2010.12.002. Epub 2010 Dec 11.
•   Hynes RO
  Integrins: bidirectional, allosteric signaling machines. Cell. 2002 Sep 20;110(6):673-87. doi: 10.1016/s0092-8674(02)00971-6.
•   Iellem A, Colantonio L, D'Ambrosio D
  Skin-versus gut-skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4+CD25+ suppressor T cells. Eur J Immunol. 2003 Jun;33(6):1488-96. doi: 10.1002/eji.200323658.
•   Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY
  Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004 Oct;21(4):527-38. doi: 10.1016/j.immuni.2004.08.011.
•   Kempster SL, Kaser A
  alpha4beta7 integrin: beyond T cell trafficking. Gut. 2014 Sep;63(9):1377-9. doi: 10.1136/gutjnl-2013-305967. Epub 2013 Dec 11. No abstract available.
•   Li L, Boussiotis VA
  Molecular and functional heterogeneity of T regulatory cells. Clin Immunol. 2011 Dec;141(3):244-52. doi: 10.1016/j.clim.2011.08.011. Epub 2011 Aug 30.
•   Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Bello I, Cilio CM, Wong FS, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society
  Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol. 2011 Jan;163(1):33-49. doi: 10.1111/j.1365-2249.2010.04272.x. Epub 2010 Oct 5.
•   McMurchy AN, Levings MK
  Suppression assays with human T regulatory cells: a technical guide. Eur J Immunol. 2012 Jan;42(1):27-34. doi: 10.1002/eji.201141651. Epub 2011 Dec 12.
•   Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C, Hamann A, Huehn J
  Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. Eur J Immunol. 2010 Sep;40(9):2539-48. doi: 10.1002/eji.200939938.
•   Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D
  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 5;96(3):319-28. doi: 10.1016/s0092-8674(00)80545-0.
•   Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT, Atreya R, Krauss E, Hundorfean G, Fichtner-Feigl S, Hartmann A, Becker C, Mudter J
  IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut. 2015 May;64(5):743-55. doi: 10.1136/gutjnl-2013-305947. Epub 2014 Jun 23.
•   Ramesh G, Alvarez X, Borda JT, Aye PP, Lackner AA, Sestak K
  Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation. Clin Diagn Lab Immunol. 2005 Jan;12(1):192-7. doi: 10.1128/CDLI.12.1.192-197.2005.
•   Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BMJ, Lohning M, Belkaid Y, Fallon PG, Powrie F
  The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature. 2014 Sep 25;513(7519):564-568. doi: 10.1038/nature13577. Epub 2014 Jul 16.
•   Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER
  The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J Pharmacol Exp Ther. 2009 Sep;330(3):864-75. doi: 10.1124/jpet.109.153973. Epub 2009 Jun 9.
•   Souza HS, Elia CC, Spencer J, MacDonald TT
  Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut. 1999 Dec;45(6):856-63. doi: 10.1136/gut.45.6.856.
•   Teague TK, Lazarovits AI, McIntyre BW
  Integrin alpha 4 beta 7 co-stimulation of human peripheral blood T cell proliferation. Cell Adhes Commun. 1994 Dec;2(6):539-47. doi: 10.3109/15419069409014217.
•   Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D
  Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20;449(7160):361-5. doi: 10.1038/nature06110. Epub 2007 Aug 12.
•   Wu X, Lahiri A, Haines GK 3rd, Flavell RA, Abraham C
  NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. J Immunol. 2014 Apr 1;192(7):3409-18. doi: 10.4049/jimmunol.1302436. Epub 2014 Mar 3.

The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis

Details for clinical trial NCT02721719