NCT00425113 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Andreu J, Cáceres J, Pallisa E, Martinez-Rodriguez M
Radiological manifestations of pulmonary tuberculosis. Eur J Radiol. 2004 Aug;51(2):139-49.
Brooks JV, Furney SK, Orme IM
Metronidazole therapy in mice infected with tuberculosis. Antimicrob Agents Chemother. 1999 May;43(5):1285-8.
Carrara S, Vincenti D, Petrosillo N, Amicosante M, Girardi E, Goletti D
Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy. Clin Infect Dis. 2004 Mar 1;38(5):754-6. Epub 2004 Feb 17.

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Metronidazole Combined With Antituberculous Chemotherapy vs. Antituberculous Chemotherapy With Placebo in Subjects With Multi-Drug Resistant Pulmonary Tuberculosis

Details for clinical trial NCT00425113

Clinical trial NCT00425113 - References