Basaran G, Ozer T, Kaya FA, Kaplan A, Hamamci O Interleukine-1beta and tumor necrosis factor-alpha levels in the human gingival sulcus during orthodontic treatment. Angle Orthod. 2006 Sep;76(5):830-6.
Bildt MM, Bloemen M, Kuijpers-Jagtman AM, Von den Hoff JW Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement. Eur J Orthod. 2009 Oct;31(5):529-35. doi: 10.1093/ejo/cjn127. Epub 2009 Mar 18.
Brosens V, Ghijselings I, Lemiere J, Fieuws S, Clijmans M, Willems G Changes in oral health-related quality of life reports in children during orthodontic treatment and the possible role of self-esteem: a follow-up study. Eur J Orthod. 2014 Apr;36(2):186-91. doi: 10.1093/ejo/cjt035. Epub 2013 Jun 6.
Brudvik P, Rygh P Root resorption after local injection of prostaglandin E2 during experimental tooth movement. Eur J Orthod. 1991 Aug;13(4):255-63.
Darendeliler MA, Zea A, Shen G, Zoellner H Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study. Aust Dent J. 2007 Dec;52(4):282-7.
Doshi-Mehta G, Bhad-Patil WA Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.
Feu D, Miguel JA, Celeste RK, Oliveira BH Effect of orthodontic treatment on oral health-related quality of life. Angle Orthod. 2013 Sep;83(5):892-8. doi: 10.2319/100412-781.1. Epub 2013 Apr 17.
Grant M, Wilson J, Rock P, Chapple I Induction of cytokines, MMP9, TIMPs, RANKL and OPG during orthodontic tooth movement. Eur J Orthod. 2013 Oct;35(5):644-51. doi: 10.1093/ejo/cjs057. Epub 2012 Sep 17.
Greabu M, Didilescu A, Puiu L, Miricescu D, Totan A Salivary antioxidant biomarkers in non-ferrous metals mine workers--a pilot study. J Oral Pathol Med. 2012 Jul;41(6):490-3. doi: 10.1111/j.1600-0714.2012.01131.x. Epub 2012 Mar 7.
John MT, Patrick DL, Slade GD The German version of the Oral Health Impact Profile--translation and psychometric properties. Eur J Oral Sci. 2002 Dec;110(6):425-33.
Jönsson A, Malmgren O, Levander E Long-term follow-up of tooth mobility in maxillary incisors with orthodontically induced apical root resorption. Eur J Orthod. 2007 Oct;29(5):482-7.
Krishnan V, Davidovitch Z On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 2009 Jul;88(7):597-608. doi: 10.1177/0022034509338914. Review.
Krishnan V, Davidovitch Z The effect of drugs on orthodontic tooth movement. Orthod Craniofac Res. 2006 Nov;9(4):163-71. Review.
Kumar S, Ram S, Navazesh M Salivary gland and associated complications in head and neck cancer therapy. J Calif Dent Assoc. 2011 Sep;39(9):639-47. Review.
Lee TY, Lee KJ, Baik HS Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading. Angle Orthod. 2009 Jul;79(4):733-9. doi: 10.2319/031308-145.1.
Leonardi R, Talic NF, Loreto C MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats. Acta Histochem. 2007;109(3):215-20. Epub 2007 Mar 9.
Liou EJ, Chen PH, Wang YC, Yu CC, Huang CS, Chen YR Surgery-first accelerated orthognathic surgery: orthodontic guidelines and setup for model surgery. J Oral Maxillofac Surg. 2011 Mar;69(3):771-80. doi: 10.1016/j.joms.2010.11.011. Epub 2011 Jan 22.
Lisboa RA, Andrade MV, Cunha-Melo JR Toll-like receptor activation and mechanical force stimulation promote the secretion of matrix metalloproteinases 1, 3 and 10 of human periodontal fibroblasts via p38, JNK and NF-kB. Arch Oral Biol. 2013 Jun;58(6):731-9. doi: 10.1016/j.archoralbio.2012.12.009. Epub 2013 Jan 14.
Locker D, Slade G Oral health and the quality of life among older adults: the oral health impact profile. J Can Dent Assoc. 1993 Oct;59(10):830-3, 837-8, 844.
Madureira DF, Taddei Sde A, Abreu MH, Pretti H, Lages EM, da Silva TA Kinetics of interleukin-6 and chemokine ligands 2 and 3 expression of periodontal tissues during orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2012 Oct;142(4):494-500. doi: 10.1016/j.ajodo.2012.05.012.
Masini V [Sexual activity after myocardial infarct]. G Ital Cardiol. 1980;10(3):241-5. Italian.
Miles P, Smith H, Weyant R, Rinchuse DJ The effects of a vibrational appliance on tooth movement and patient discomfort: a prospective randomised clinical trial. Aust Orthod J. 2012 Nov;28(2):213-8.
Nagase S, Hashimoto Y, Small M, Ohyama M, Kuwayama T, Deacon S Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women. Br J Clin Pharmacol. 2012 Dec;74(6):959-70. doi: 10.1111/j.1365-2125.2012.04307.x.
Nammontri O, Robinson PG, Baker SR Enhancing oral health via sense of coherence: a cluster-randomized trial. J Dent Res. 2013 Jan;92(1):26-31. doi: 10.1177/0022034512459757. Epub 2012 Sep 27.
Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K, Mitani H Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. Am J Orthod Dentofacial Orthop. 2008 Apr;133(4):572-83. doi: 10.1016/j.ajodo.2006.01.046.
Palomares NB, Celeste RK, Oliveira BH, Miguel JA How does orthodontic treatment affect young adults' oral health-related quality of life? Am J Orthod Dentofacial Orthop. 2012 Jun;141(6):751-8. doi: 10.1016/j.ajodo.2012.01.015.
Ram S, Kumar S, Navazesh M Management of xerostomia and salivary gland hypofunction. J Calif Dent Assoc. 2011 Sep;39(9):656-9.
Roy EA, Hollins M, Maixner W Reduction of TMD pain by high-frequency vibration: a spatial and temporal analysis. Pain. 2003 Feb;101(3):267-74. Erratum in: Pain. 2003 Aug;104(3):717.
Slade GD, Reisine ST The child oral health impact profile: current status and future directions. Community Dent Oral Epidemiol. 2007 Aug;35 Suppl 1:50-3.
Slade GD Assessing change in quality of life using the Oral Health Impact Profile. Community Dent Oral Epidemiol. 1998 Feb;26(1):52-61.
Slade GD Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol. 1997 Aug;25(4):284-90.
Tecco S, D'Attilio M, Tetè S, Festa F Prevalence and type of pain during conventional and self-ligating orthodontic treatment. Eur J Orthod. 2009 Aug;31(4):380-4. doi: 10.1093/ejo/cjp003. Epub 2009 May 22.
Tecco S, Tetè S, Perillo L, Chimenti C, Festa F Maxillary arch width changes during orthodontic treatment with fixed self-ligating and traditional straight-wire appliances. World J Orthod. 2009 Winter;10(4):290-4.
Umesan UK, Chua KL, Krishnan V Assessing salivary biomarkers for analyzing orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2013 Apr;143(4):446-7. doi: 10.1016/j.ajodo.2013.02.006.
Vs K, K P, Ramesh M, Venkatesan V The association of serum osteocalcin with the bone mineral density in post menopausal women. J Clin Diagn Res. 2013 May;7(5):814-6. doi: 10.7860/JCDR/2013/5370.2946. Epub 2013 Mar 20.
Yu CC, Chen PH, Liou EJ, Huang CS, Chen YR A Surgery-first approach in surgical-orthodontic treatment of mandibular prognathism--a case report. Chang Gung Med J. 2010 Nov-Dec;33(6):699-705.
Zhang C, Li J, Zhang L, Zhou Y, Hou W, Quan H, Li X, Chen Y, Yu H Effects of mechanical vibration on proliferation and osteogenic differentiation of human periodontal ligament stem cells. Arch Oral Biol. 2012 Oct;57(10):1395-407. doi: 10.1016/j.archoralbio.2012.04.010. Epub 2012 May 15.
Zhao L, Wu Z, Zhang Y Low-magnitude mechanical vibration may be applied clinically to promote dental implant osseointegration. Med Hypotheses. 2009 Apr;72(4):451-2. doi: 10.1016/j.mehy.2008.10.023. Epub 2009 Jan 12.
Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy: A Randomized Clinical Trial
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.