Tinnitus, Noise Induced — TNF-α Treatment of Blast-Induced Tinnitus
Citation(s)
Akkuzu B, Yilmaz I, Cakmak O, Ozluoglu LN Efficacy of misoprostol in the treatment of tinnitus in patients with diabetes and/or hypertension. Auris Nasus Larynx. 2004 Sep;31(3):226-32. doi: 10.1016/j.anl.2004.03.005.
Andersson G, Lyttkens L, Larsen HC Distinguishing levels of tinnitus distress. Clin Otolaryngol Allied Sci. 1999 Sep;24(5):404-10. doi: 10.1046/j.1365-2273.1999.00278.x.
Andersson G Tinnitus loudness matchings in relation to annoyance and grading of severity. Auris Nasus Larynx. 2003 May;30(2):129-33. doi: 10.1016/s0385-8146(03)00008-7.
Andrews JA, Neises KD Cells, biomarkers, and post-traumatic stress disorder: evidence for peripheral involvement in a central disease. J Neurochem. 2012 Jan;120(1):26-36. doi: 10.1111/j.1471-4159.2011.07545.x. Epub 2011 Nov 17.
Briner W, House J, O'Leary M Synthetic prostaglandin E1 misoprostol as a treatment for tinnitus. Arch Otolaryngol Head Neck Surg. 1993 Jun;119(6):652-4. doi: 10.1001/archotol.1993.01880180068013.
Brozoski T, Odintsov B, Bauer C Gamma-aminobutyric acid and glutamic acid levels in the auditory pathway of rats with chronic tinnitus: a direct determination using high resolution point-resolved proton magnetic resonance spectroscopy (H-MRS). Front Syst Neurosci. 2012 Feb 24;6:9. doi: 10.3389/fnsys.2012.00009. eCollection 2012.
Covey WC, Ignatowski TA, Knight PR, Spengler RN Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Res. 2000 Mar 17;859(1):113-22. doi: 10.1016/s0006-8993(00)01965-x.
Crocetti A, Forti S, Ambrosetti U, Bo LD Questionnaires to evaluate anxiety and depressive levels in tinnitus patients. Otolaryngol Head Neck Surg. 2009 Mar;140(3):403-5. doi: 10.1016/j.otohns.2008.11.036.
De Ridder D, Elgoyhen AB, Romo R, Langguth B Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8075-80. doi: 10.1073/pnas.1018466108. Epub 2011 Apr 18.
Eyre H, Baune BT Neuroplastic changes in depression: a role for the immune system. Psychoneuroendocrinology. 2012 Sep;37(9):1397-416. doi: 10.1016/j.psyneuen.2012.03.019. Epub 2012 Apr 21.
Falkenberg ES, Wie OB Anxiety and depression in tinnitus patients: 5-year follow-up assessment after completion of habituation therapy. Int J Otolaryngol. 2012;2012:375460. doi: 10.1155/2012/375460. Epub 2012 Mar 28.
Folstein MF, Folstein SE, McHugh PR "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.
Halford JB, Anderson SD Anxiety and depression in tinnitus sufferers. J Psychosom Res. 1991;35(4-5):383-90. doi: 10.1016/0022-3999(91)90033-k.
Hansel A, Hong S, Camara RJ, von Kanel R Inflammation as a psychophysiological biomarker in chronic psychosocial stress. Neurosci Biobehav Rev. 2010 Sep;35(1):115-21. doi: 10.1016/j.neubiorev.2009.12.012. Epub 2009 Dec 22.
Hebert S, Fullum S, Carrier J Polysomnographic and quantitative electroencephalographic correlates of subjective sleep complaints in chronic tinnitus. J Sleep Res. 2011 Mar;20(1 Pt 1):38-44. doi: 10.1111/j.1365-2869.2010.00860.x.
Henry JL, Wilson PH Coping with Tinnitus: Two Studies of Psychological and Audiological Characteristics of Patients with High and Low Tinnitus-Related Distress. Int Tinnitus J. 1995;1(2):85-92.
Herbert TB, Cohen S Stress and immunity in humans: a meta-analytic review. Psychosom Med. 1993 Jul-Aug;55(4):364-79. doi: 10.1097/00006842-199307000-00004.
Hesser H, Westin V, Hayes SC, Andersson G Clients' in-session acceptance and cognitive defusion behaviors in acceptance-based treatment of tinnitus distress. Behav Res Ther. 2009 Jun;47(6):523-8. doi: 10.1016/j.brat.2009.02.002. Epub 2009 Feb 10.
Hiller W, Goebel G A psychometric study of complaints in chronic tinnitus. J Psychosom Res. 1992 May;36(4):337-48. doi: 10.1016/0022-3999(92)90070-i.
Hwang JH, Chen JC, Yang SY, Wang MF, Chan YC Expression of tumor necrosis factor-alpha and interleukin-1beta genes in the cochlea and inferior colliculus in salicylate-induced tinnitus. J Neuroinflammation. 2011 Apr 9;8:30. doi: 10.1186/1742-2094-8-30.
Llano DA, Turner J, Caspary DM Diminished cortical inhibition in an aging mouse model of chronic tinnitus. J Neurosci. 2012 Nov 14;32(46):16141-8. doi: 10.1523/JNEUROSCI.2499-12.2012.
Middleton JW, Kiritani T, Pedersen C, Turner JG, Shepherd GM, Tzounopoulos T Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7601-6. doi: 10.1073/pnas.1100223108. Epub 2011 Apr 18.
Moller AR Similarities between chronic pain and tinnitus. Am J Otol. 1997 Sep;18(5):577-85.
Rahman MU, Poe DS, Choi HK Etanercept therapy for immune-mediated cochleovestibular disorders: preliminary results in a pilot study. Otol Neurotol. 2001 Sep;22(5):619-24. doi: 10.1097/00129492-200109000-00010.
Rossiter S, Stevens C, Walker G Tinnitus and its effect on working memory and attention. J Speech Lang Hear Res. 2006 Feb;49(1):150-60. doi: 10.1044/1092-4388(2006/012).
Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM Tumor necrosis factor-alpha, an initiator, and etanercept, an inhibitor of cochlear inflammation. Laryngoscope. 2002 Sep;112(9):1627-34. doi: 10.1097/00005537-200209000-00019. Erratum In: Laryngoscope. 2003 Jun;4(2):291.
Schaette R, Kempter R Computational models of neurophysiological correlates of tinnitus. Front Syst Neurosci. 2012 May 8;6:34. doi: 10.3389/fnsys.2012.00034. eCollection 2012.
Scott B, Lindberg P, Melin L, Lyttkens L Predictors of tinnitus discomfort, adaptation and subjective loudness. Br J Audiol. 1990 Feb;24(1):51-62. doi: 10.3109/03005369009077842.
Seydel C, Haupt H, Olze H, Szczepek AJ, Mazurek B Gender and chronic tinnitus: differences in tinnitus-related distress depend on age and duration of tinnitus. Ear Hear. 2013 Sep;34(5):661-72. doi: 10.1097/AUD.0b013e31828149f2.
Steinmetz CC, Turrigiano GG Tumor necrosis factor-alpha signaling maintains the ability of cortical synapses to express synaptic scaling. J Neurosci. 2010 Nov 3;30(44):14685-90. doi: 10.1523/JNEUROSCI.2210-10.2010.
Stellwagen D, Beattie EC, Seo JY, Malenka RC Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci. 2005 Mar 23;25(12):3219-28. doi: 10.1523/JNEUROSCI.4486-04.2005. Erratum In: J Neurosci. 2005 Jun 1;25(22):1 p following 5454.
Stellwagen D, Malenka RC Synaptic scaling mediated by glial TNF-alpha. Nature. 2006 Apr 20;440(7087):1054-9. doi: 10.1038/nature04671. Epub 2006 Mar 19.
Steptoe A, Hamer M, Chida Y The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun. 2007 Oct;21(7):901-12. doi: 10.1016/j.bbi.2007.03.011. Epub 2007 May 1.
Stevens C, Walker G, Boyer M, Gallagher M Severe tinnitus and its effect on selective and divided attention. Int J Audiol. 2007 May;46(5):208-16. doi: 10.1080/14992020601102329.
Szczepek AJ, Haupt H, Klapp BF, Olze H, Mazurek B Biological correlates of tinnitus-related distress: an exploratory study. Hear Res. 2014 Dec;318:23-30. doi: 10.1016/j.heares.2014.10.007. Epub 2014 Oct 28.
Tonndorf J The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. Hear Res. 1987;28(2-3):271-5. doi: 10.1016/0378-5955(87)90054-2.
Tyler RS, Gogel SA, Gehringer AK Tinnitus activities treatment. Prog Brain Res. 2007;166:425-34. doi: 10.1016/S0079-6123(07)66041-5.
Van Wijk F, Staecker H, Keithley E, Lefebvre PP Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol. 2006;11(6):357-65. doi: 10.1159/000095897. Epub 2006 Sep 21.
VBA VA Annual Benefits Report: Fiscal Year 2012. In: VA US, ed. 810 Vermont Avenue N. W. , Washington, D.C., 20420: Veterans Benefits Administration, 2013:82.
Wang HT, Luo B, Zhou KQ, Xu TL, Chen L Sodium salicylate reduces inhibitory postsynaptic currents in neurons of rat auditory cortex. Hear Res. 2006 May;215(1-2):77-83. doi: 10.1016/j.heares.2006.03.004. Epub 2006 Apr 24.
Weber C, Arck P, Mazurek B, Klapp BF Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers. J Psychosom Res. 2002 Jan;52(1):29-33. doi: 10.1016/s0022-3999(01)00281-1.
Weinberg MS, Blake BL, McCown TJ Opposing actions of hippocampus TNFalpha receptors on limbic seizure susceptibility. Exp Neurol. 2013 Sep;247:429-37. doi: 10.1016/j.expneurol.2013.01.011. Epub 2013 Jan 16.
Widomski D, Fretland DJ, Gasiecki AF, Collins PW The prostaglandin analogs, misoprostol and SC-46275, potently inhibit cytokine release from activated human monocytes. Immunopharmacol Immunotoxicol. 1997 May;19(2):165-74. doi: 10.3109/08923979709007656.
Yang S, Bao S Homeostatic mechanisms and treatment of tinnitus. Restor Neurol Neurosci. 2013;31(2):99-108. doi: 10.3233/RNN-120248.
Yang S, Weiner BD, Zhang LS, Cho SJ, Bao S Homeostatic plasticity drives tinnitus perception in an animal model. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14974-9. doi: 10.1073/pnas.1107998108. Epub 2011 Sep 6.
Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.