NCT03943069 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Alayouty HD, Hasan TM, Alhadad ZA, Omar Barabba R
Mechanical versus chemical pleurodesis for management of primary spontaneous pneumothorax evaluated with thoracic echography. Interact Cardiovasc Thorac Surg. 2011 Nov;13(5):475-9. doi: 10.1510/icvts.2011.270280. Epub 2011 Aug 9.
Grundy S, Bentley A, Tschopp JM
Primary spontaneous pneumothorax: a diffuse disease of the pleura. Respiration. 2012;83(3):185-9. doi: 10.1159/000335993. Epub 2012 Feb 15. Review.
Horio H, Nomori H, Kobayashi R, Naruke T, Suemasu K
Impact of additional pleurodesis in video-assisted thoracoscopic bullectomy for primary spontaneous pneumothorax. Surg Endosc. 2002 Apr;16(4):630-4. Epub 2002 Jan 9.
Huh U, Kim YD, Cho JS, I H, Lee JG, Lee JH
The Effect of Thoracoscopic Pleurodesis in Primary Spontaneous Pneumothorax: Apical Parietal Pleurectomy versus Pleural Abrasion. Korean J Thorac Cardiovasc Surg. 2012 Oct;45(5):316-9. doi: 10.5090/kjtcs.2012.45.5.316. Epub 2012 Oct 9.
Noppen M, Baumann MH
Pathogenesis and treatment of primary spontaneous pneumothorax: an overview. Respiration. 2003 Jul-Aug;70(4):431-8. Review.
Noppen M, De Keukeleire T
Pneumothorax. Respiration. 2008;76(2):121-7. doi: 10.1159/000135932. Epub 2008 Jun 26. Review.
Noppen M
Spontaneous pneumothorax: epidemiology, pathophysiology and cause. Eur Respir Rev. 2010 Sep;19(117):217-9. doi: 10.1183/09059180.00005310. Review.
Zhang Z, Du L, Feng H, Liang C, Liu D
Pleural abrasion should not routinely preferred in treatment of primary spontaneous pneumothorax. J Thorac Dis. 2017 Apr;9(4):1119-1125. doi: 10.21037/jtd.2017.03.124.

Thoracoscopic Bullectomy Versus Thoracoscopic Bullectomy and Pleurodesis For Management of Primary Spontaneous Pneumothorax; A Prospective Multicenter Randomized Controlled Study

Details for clinical trial NCT03943069

Clinical trial NCT03943069 - References