Tetanus — Intrathecal Tetanus Immunoglobulin to Treat Tetanus
Citation(s)
Abrutyn E, Berlin JA Intrathecal therapy in tetanus. A meta-analysis. JAMA. 1991 Oct 23-30;266(16):2262-7.
Agarwal M, Thomas K, Peter JV, Jeyaseelan L, Cherian AM A randomized double-blind sham-controlled study of intrathecal human anti-tetanus immunoglobulin in the management of tetanus. Natl Med J India. 1998 Sep-Oct;11(5):209-12.
Ahmad A, Qaisar I, Naeem M, Mazhar AU, Ashfaq M Intrathecal anti-tetanus human immunoglobulin in the treatment of neonatal tetanus. J Coll Physicians Surg Pak. 2011 Sep;21(9):539-41. doi: 09.2011/JCPSP.539541.
Andrewes F On the intrathecal route for the administration of tetanus antitoxin. Lancet. 1917;189(May):682-6
Dodou K Intrathecal route of drug delivery can save lives or improve quality of life [Internet]. Pharmaceutical Journal. 2012. p. 9-12. Available from: http://www.pjonline.com/news/intrathecal_route_of_drug_delivery_can_save_lives_or_improve_quality_of_life
Dodou K Intrathecal route of drug delivery can save lives or improve quality of life. Pharmaceutical Journal. 2012. p. 9-12
Eisenach JC, Shafer SL, Yaksh T The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 2010 Jun;149(3):417-9. doi: 10.1016/j.pain.2010.02.028. Epub 2010 Mar 15.
Florey H, Fildes P Tetanus . -Vii . the Treatment of Tetanus in Rabbits By Large Intrathecal Doses of Antitoxin . Br J Exp Pathol. 1927;(October):393-7
FRIEDEMANN U, TRAUB FB Pathogenesis of local tetanus in the dog and the cat. J Immunol. 1949 Sep;63(1):23-8.
Geeta MG, Krishnakumar P, Mathews L Intrathecal tetanus immunoglobulins in the management of tetanus. Indian J Pediatr. 2007 Jan;74(1):43-5.
Govindaraj GM, Riyaz A Current practice in the management of tetanus. Crit Care. 2014 May 27;18(3):145. doi: 10.1186/cc13894.
Health Protection Agency HPA expert working group interim guidance on the use of tetanus immunoglobulin for the treatment of Tetanus [Internet]. 2013. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/400084/expert_working_group_interim_guidance_on_the_use_of_tetanus_immunoglobulin_for_the_treatment_of_Tetanus.pdf
Health Protection Agency Tetanus [Internet]. Information for Health Professionals. 2013. Available from: http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1194947374762
Ildirim I A new treatment for neonatal tetanus. Antitetanic serum and prednisolone given together intrathecally. Turk J Pediatr. 1967 Jul;9(3):89-95.
Ildirim I Intrathecal serotherapy of tetanus. I. Explanation of complications. II. Comparison of intrathecal tetanus immune globulin and tetanus antitoxin. Turk J Pediatr. 1974 Jul;16(3):103-10.
Jiang D, Pu X, Wu J, Li M, Liu P Rapid, sensitive, and specific detection of Clostridium tetani by loop-mediated isothermal amplification assay. J Microbiol Biotechnol. 2013 Jan;23(1):1-6.
Kabura L, Ilibagiza D, Menten J, Van den Ende J Intrathecal vs. intramuscular administration of human antitetanus immunoglobulin or equine tetanus antitoxin in the treatment of tetanus: a meta-analysis. Trop Med Int Health. 2006 Jul;11(7):1075-81. Review.
Lalli G, Schiavo G Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR. J Cell Biol. 2002 Jan 21;156(2):233-9. Epub 2002 Jan 21.
Lee IO, Son JK, Lim ES, Kim YS Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice. J Korean Med Sci. 2011 Oct;26(10):1371-7. doi: 10.3346/jkms.2011.26.10.1371. Epub 2011 Oct 1.
Lim ES, Lee IO Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice. Korean J Anesthesiol. 2010 Jan;58(1):76-86. doi: 10.4097/kjae.2010.58.1.76. Epub 2010 Jan 31.
McCracken GH Jr, Dowell DL, Marshall FN Double-blind trial of equine antitoxin and human immune globulin in tetanus neonatorum. Lancet. 1971 Jun 5;1(7710):1146-9.
Mchil Ugwu GI Neonatal Tetanus in Varri Niger Delta: A Ten Year Retrospective Study. CJMedRes. 2010;4:3-7
Menon J, Mathews L Intrathecal immunoglobulin in the treatment of tetanus. Indian Pediatr. 2002 Jul;39(7):654-7.
Mongi PS, Mbise RL, Msengi AE, Do Amsi DM Tetanus neonatorum--experience with intrathecal serotherapy at Muhimbili Medical Centre, Dar es Salaam, Tanzania. Ann Trop Paediatr. 1987 Mar;7(1):27-31.
Rodrigo C, Fernando D, Rajapakse S Pharmacological management of tetanus: an evidence-based review. Crit Care. 2014 Mar 26;18(2):217. doi: 10.1186/cc13797. Review.
Roux E, Borrel A Tetanos Cerebral et immunite contre le tetanus. Ann Inst Pasteur (Paris) [Internet]. 1898;12(4):525-35. Available from: https://archive.org/stream/annalesdelinstit12inst
Rowbotham MC PAIN's policy on the spinal administration of drugs. Pain [Internet]. International Association for the Study of Pain; 2010;149(3):415-6. Available from: http://dx.doi.org/10.1016/j.pain.2010.02.027
Sedaghatian MR Intrathecal serotherapy in neonatal tetanus: a controlled trial. Arch Dis Child. 1979 Aug;54(8):623-5.
Sherrington BYCS The serum treatment of experimental tetanus in monkeys. Lancet. 1917;964:54-68
Smith JW, Schallibaum EM The therapeutic effect of homologous and heterologous antitoxins in experimental diphtheria and tetanus. Br J Exp Pathol. 1970 Feb;51(1):73-80.
Smith JW Intracerebral antitoxin in experimental tetanus. Br J Exp Pathol. 1966 Feb;47(1):17-24.
Turillazzi E, Neri M, Pomara C, Riezzo I, Fineschi V An immunohistochemical study on a tetanus fatal case using toxin fragment C (TTC). Should it be a useful diagnostic tool? Neuropathology. 2009 Feb;29(1):68-71. doi: 10.1111/j.1440-1789.2008.00912.x. Epub 2008 Apr 15.
Wateba M, Diop S, Nichols S, Patassi A, Adjo S, Gbadamassi G, Tidjani O [Intrathecal therapy with 1 500 UI of antitetanic serum and 1.5 g of intravenous metronidazole: prognosis of tetanus in hospitalized patients in Togo]. Sante. 2008 Jul-Sep;18(3):125-9. doi: 10.1684/san.2008.0115. French.
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
