Syringomyelia — Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
Citation(s)
Arnautovic A, Splavski B, Boop FA, Arnautovic KI Pediatric and adult Chiari malformation Type I surgical series 1965-2013: a review of demographics, operative treatment, and outcomes. J Neurosurg Pediatr. 2015 Feb;15(2):161-77. doi: 10.3171/2014.10.PEDS14295. Epub 2014 Dec 5.
Batzdorf U Primary spinal syringomyelia. Invited submission from the joint section meeting on disorders of the spine and peripheral nerves, March 2005. J Neurosurg Spine. 2005 Dec;3(6):429-35. Review.
Durham SR, Fjeld-Olenec K Comparison of posterior fossa decompression with and without duraplasty for the surgical treatment of Chiari malformation Type I in pediatric patients: a meta-analysis. J Neurosurg Pediatr. 2008 Jul;2(1):42-9. doi: 10.3171/PED/2008/2/7/042.
Gail M, Simon R Testing for qualitative interactions between treatment effects and patient subsets. Biometrics. 1985 Jun;41(2):361-72.
Galarza M, Sood S, Ham S Relevance of surgical strategies for the management of pediatric Chiari type I malformation. Childs Nerv Syst. 2007 Jun;23(6):691-6. Epub 2007 Jan 25.
Greenberg JK, et al (2014) Population-Based Analysis of Complications Associated with Chiari Malformation Type 1 Surgery in Children. AANS/CNS Joint Section on Pediatric Neurosurgery.
Guyatt GH, Kirshner B, Jaeschke R Measuring health status: what are the necessary measurement properties? J Clin Epidemiol. 1992 Dec;45(12):1341-5.
Hankinson T, Tubbs RS, Wellons JC Duraplasty or not? An evidence-based review of the pediatric Chiari I malformation. Childs Nerv Syst. 2011 Jan;27(1):35-40. doi: 10.1007/s00381-010-1295-7. Epub 2010 Oct 2. Review.
Hida K, Iwasaki Y, Koyanagi I, Abe H Pediatric syringomyelia with chiari malformation: its clinical characteristics and surgical outcomes. Surg Neurol. 1999 Apr;51(4):383-90; discussion 390-1.
Kirshner B, Guyatt G A methodological framework for assessing health indices. J Chronic Dis. 1985;38(1):27-36.
Ladner TR, Westrick AC, Wellons JC 3rd, Shannon CN Health-related quality of life in pediatric Chiari Type I malformation: the Chiari Health Index for Pediatrics. J Neurosurg Pediatr. 2016 Jan;17(1):76-85. doi: 10.3171/2015.5.PEDS1513. Epub 2015 Oct 2.
Lee A, Yarbrough CK, Greenberg JK, Barber J, Limbrick DD, Smyth MD Comparison of posterior fossa decompression with or without duraplasty in children with Type I Chiari malformation. Childs Nerv Syst. 2014 Aug;30(8):1419-24. doi: 10.1007/s00381-014-2424-5. Epub 2014 Apr 29.
Limonadi FM, Selden NR Dura-splitting decompression of the craniocervical junction: reduced operative time, hospital stay, and cost with equivalent early outcome. J Neurosurg. 2004 Nov;101(2 Suppl):184-8.
Marcus DS, Olsen TR, Ramaratnam M, Buckner RL The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data. Neuroinformatics. 2007 Spring;5(1):11-34.
Mueller D, Oro' JJ Prospective analysis of self-perceived quality of life before and after posterior fossa decompression in 112 patients with Chiari malformation with or without syringomyelia. Neurosurg Focus. 2005 Feb 15;18(2):ECP2.
Mutchnick IS, Janjua RM, Moeller K, Moriarty TM Decompression of Chiari malformation with and without duraplasty: morbidity versus recurrence. J Neurosurg Pediatr. 2010 May;5(5):474-8. doi: 10.3171/2010.1.PEDS09218.
Rocque BG, George TM, Kestle J, Iskandar BJ Treatment practices for Chiari malformation type I with syringomyelia: results of a survey of the American Society of Pediatric Neurosurgeons. J Neurosurg Pediatr. 2011 Nov;8(5):430-7. doi: 10.3171/2011.8.PEDS10427.
Small JA, Sheridan PH Research priorities for syringomyelia: a National Institute of Neurological Disorders and Stroke workshop summary. Neurology. 1996 Feb;46(2):577-82.
Tisell M, Wallskog J, Linde M Long-term outcome after surgery for Chiari I malformation. Acta Neurol Scand. 2009 Nov;120(5):295-9. doi: 10.1111/j.1600-0404.2009.01183.x. Epub 2009 Jun 11.
Vakharia VN, Guilfoyle MR, Laing RJ Prospective study of outcome of foramen magnum decompressions in patients with syrinx and non-syrinx associated Chiari malformations. Br J Neurosurg. 2012 Feb;26(1):7-11. doi: 10.3109/02688697.2011.578771. Epub 2011 May 18.
Ventureyra EC, Aziz HA, Vassilyadi M The role of cine flow MRI in children with Chiari I malformation. Childs Nerv Syst. 2003 Feb;19(2):109-13. Epub 2003 Jan 30.
Yeh DD, Koch B, Crone KR Intraoperative ultrasonography used to determine the extent of surgery necessary during posterior fossa decompression in children with Chiari malformation type I. J Neurosurg. 2006 Jul;105(1 Suppl):26-32.
Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
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