Surgical Wound Infection — Skin Perfusion After Abdominal Surgery
Citation(s)
Boltz MM, Hollenbeak CS, Julian KG, Ortenzi G, Dillon PW Hospital costs associated with surgical site infections in general and vascular surgery patients. Surgery. 2011 Nov;150(5):934-42. doi: 10.1016/j.surg.2011.04.006. Epub 2011 Jun 15.
de Weerd L, Mercer JB, Weum S Dynamic infrared thermography. Clin Plast Surg. 2011 Apr;38(2):277-92. doi: 10.1016/j.cps.2011.03.013.
de Weerd L, Miland AO, Mercer JB Perfusion dynamics of free DIEP and SIEA flaps during the first postoperative week monitored with dynamic infrared thermography. Ann Plast Surg. 2009 Jan;62(1):42-7. doi: 10.1097/SAP.0b013e3181776374.
Dhar SC, Taylor GI The delay phenomenon: the story unfolds. Plast Reconstr Surg. 1999 Dec;104(7):2079-91.
Huger WE Jr The anatomic rationale for abdominal lipectomy. Am Surg. 1979 Sep;45(9):612-7.
Hunt TK, Hopf H, Hussain Z Physiology of wound healing. Adv Skin Wound Care. 2000 May-Jun;13(2 Suppl):6-11. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.