Stroke — Effects of Transcranial Direct Current Stimulation (tDCS) on Language
Citation(s)
Baker JM, Rorden C, Fridriksson J Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke. 2010 Jun;41(6):1229-36. doi: 10.1161/STROKEAHA.109.576785. Epub 2010 Apr 15.
Bikson M, Datta A, Elwassif M Establishing safety limits for transcranial direct current stimulation. Clin Neurophysiol. 2009 Jun;120(6):1033-4. doi: 10.1016/j.clinph.2009.03.018. Epub 2009 Apr 24. No abstract available.
Boyle M, Coelho CA Application of semantic feature analysis as a treatment for aphasic dysnomia. Am. J. Speech Lang. Pathol. 1995;4(4):94-98
Boysen AE, Wertz RT Clinician Costs in Aphasia Treatment: How Much Is a Word Worth? Clin. Aphasiology 1996;24:207-213.
Brady MC, Kelly H, Godwin J, Enderby P Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev. 2012 May 16;(5):CD000425. doi: 10.1002/14651858.CD000425.pub3.
Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol. 2011 Sep;14(8):1133-45. doi: 10.1017/S1461145710001690. Epub 2011 Feb 15.
Cohen Kadosh R, Soskic S, Iuculano T, Kanai R, Walsh V Modulating neuronal activity produces specific and long-lasting changes in numerical competence. Curr Biol. 2010 Nov 23;20(22):2016-20. doi: 10.1016/j.cub.2010.10.007. Epub 2010 Nov 4.
Darkow R, Martin A, Wurtz A, Floel A, Meinzer M Transcranial direct current stimulation effects on neural processing in post-stroke aphasia. Hum Brain Mapp. 2017 Mar;38(3):1518-1531. doi: 10.1002/hbm.23469. Epub 2016 Nov 11.
Ellis C, Dismuke C, Edwards KK Longitudinal trends in aphasia in the United States. NeuroRehabilitation. 2010;27(4):327-33. doi: 10.3233/NRE-2010-0616.
Gandiga PC, Hummel FC, Cohen LG Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin Neurophysiol. 2006 Apr;117(4):845-50. doi: 10.1016/j.clinph.2005.12.003. Epub 2006 Jan 19.
Greener J, Enderby P, Whurr R Pharmacological treatment for aphasia following stroke. Cochrane Database Syst Rev. 2001;2001(4):CD000424. doi: 10.1002/14651858.CD000424.
Hamilton RH, Chrysikou EG, Coslett B Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang. 2011 Jul;118(1-2):40-50. doi: 10.1016/j.bandl.2011.02.005. Epub 2011 Apr 2.
Holland R, Crinion J Can tDCS enhance treatment of aphasia after stroke? Aphasiology. 2012 Sep;26(9):1169-1191. doi: 10.1080/02687038.2011.616925. Epub 2011 Nov 3.
Jordan LC, Hillis AE Disorders of speech and language: aphasia, apraxia and dysarthria. Curr Opin Neurol. 2006 Dec;19(6):580-5. doi: 10.1097/WCO.0b013e3280109260.
Jung IY, Lim JY, Kang EK, Sohn HM, Paik NJ The Factors Associated with Good Responses to Speech Therapy Combined with Transcranial Direct Current Stimulation in Post-stroke Aphasic Patients. Ann Rehabil Med. 2011 Aug;35(4):460-9. doi: 10.5535/arm.2011.35.4.460. Epub 2011 Aug 31.
Kang EK, Kim YK, Sohn HM, Cohen LG, Paik NJ Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area. Restor Neurol Neurosci. 2011;29(3):141-52. doi: 10.3233/RNN-2011-0587.
Leonard C, Rochon E, Laird L Treating naming impairments in aphasia: Findings from a phonological components analysis treatment. Aphasiology 2008;22(9):923-947.
Liebetanz D, Nitsche MA, Tergau F, Paulus W Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain. 2002 Oct;125(Pt 10):2238-47. doi: 10.1093/brain/awf238.
Meinzer M, Darkow R, Lindenberg R, Floel A Electrical stimulation of the motor cortex enhances treatment outcome in post-stroke aphasia. Brain. 2016 Apr;139(Pt 4):1152-63. doi: 10.1093/brain/aww002. Epub 2016 Feb 16.
Meinzer M, Djundja D, Barthel G, Elbert T, Rockstroh B Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy. Stroke. 2005 Jul;36(7):1462-6. doi: 10.1161/01.STR.0000169941.29831.2a. Epub 2005 Jun 9.
Nitsche MA, Liebetanz D, Lang N, Antal A, Tergau F, Paulus W Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clin Neurophysiol. 2003 Nov;114(11):2220-2; author reply 2222-3. doi: 10.1016/s1388-2457(03)00235-9. No abstract available.
Nitsche MA, Paulus W Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000 Sep 15;527 Pt 3(Pt 3):633-9. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x.
Nitsche MA, Paulus W Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001 Nov 27;57(10):1899-901. doi: 10.1212/wnl.57.10.1899.
Paulus W Transcranial direct current stimulation (tDCS). Suppl Clin Neurophysiol. 2003;56:249-54. doi: 10.1016/s1567-424x(09)70229-6.
Poreisz C, Boros K, Antal A, Paulus W Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain Res Bull. 2007 May 30;72(4-6):208-14. doi: 10.1016/j.brainresbull.2007.01.004. Epub 2007 Jan 24.
van Hees S, Angwin A, McMahon K, Copland D A comparison of semantic feature analysis and phonological components analysis for the treatment of naming impairments in aphasia. Neuropsychol Rehabil. 2013;23(1):102-32. doi: 10.1080/09602011.2012.726201. Epub 2012 Oct 26.
Vestito L, Rosellini S, Mantero M, Bandini F Long-term effects of transcranial direct-current stimulation in chronic post-stroke aphasia: a pilot study. Front Hum Neurosci. 2014 Oct 14;8:785. doi: 10.3389/fnhum.2014.00785. eCollection 2014.
You DS, Kim DY, Chun MH, Jung SE, Park SJ Cathodal transcranial direct current stimulation of the right Wernicke's area improves comprehension in subacute stroke patients. Brain Lang. 2011 Oct;119(1):1-5. doi: 10.1016/j.bandl.2011.05.002.
Effects of tDCS in Language Recovery and Reorganization in Chronic Aphasia
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.