Leonardi M, Fheodoroff K Goal Setting with ICF (International Classification of Functioning, Disability and Health) and Multidisciplinary Team Approach in Stroke Rehabilitation. 2021 Jan 15. In: Platz T, editor. Clinical Pathways in Stroke Rehabilitation: Evidence-based Clinical Practice Recommendations [Internet]. Cham (CH): Springer; 2021. Available from http://www.ncbi.nlm.nih.gov/books/NBK585584/
Rosewilliam S, Roskell CA, Pandyan AD A systematic review and synthesis of the quantitative and qualitative evidence behind patient-centred goal setting in stroke rehabilitation. Clin Rehabil. 2011 Jun;25(6):501-14. doi: 10.1177/0269215510394467. Epub 2011 Mar 25.
Sugavanam T, Mead G, Bulley C, Donaghy M, van Wijck F The effects and experiences of goal setting in stroke rehabilitation - a systematic review. Disabil Rehabil. 2013 Feb;35(3):177-90. doi: 10.3109/09638288.2012.690501. Epub 2012 Jun 7.
Wonsetler EC, Bowden MG A systematic review of mechanisms of gait speed change post-stroke. Part 2: exercise capacity, muscle activation, kinetics, and kinematics. Top Stroke Rehabil. 2017 Jul;24(5):394-403. doi: 10.1080/10749357.2017.1282413. Epub 2017 Feb 20.
Effectiveness of Physiotherapy for Improving Functionality, Participation and Quality of Life After a Stroke: Single-blind Randomized Controlled Clinical Trial
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
