Spondylolisthesis — Intercorporal Bone Graft Measurement Study
Citation(s)
Brantigan JW, Steffee AD A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results in the first 26 patients. Spine (Phila Pa 1976). 1993 Oct 15;18(14):2106-7. doi: 10.1097/00007632-199310001-00030.
Bridwell KH, Lenke LG, McEnery KW, Baldus C, Blanke K Anterior fresh frozen structural allografts in the thoracic and lumbar spine. Do they work if combined with posterior fusion and instrumentation in adult patients with kyphosis or anterior column defects? Spine (Phila Pa 1976). 1995 Jun 15;20(12):1410-8.
Brodsky AE, Kovalsky ES, Khalil MA Correlation of radiologic assessment of lumbar spine fusions with surgical exploration. Spine (Phila Pa 1976). 1991 Jun;16(6 Suppl):S261-5. doi: 10.1097/00007632-199106001-00017.
Carreon LY, Glassman SD, Schwender JD, Subach BR, Gornet MF, Ohno S Reliability and accuracy of fine-cut computed tomography scans to determine the status of anterior interbody fusions with metallic cages. Spine J. 2008 Nov-Dec;8(6):998-1002. doi: 10.1016/j.spinee.2007.12.004. Epub 2008 Feb 14.
Christensen FB, Laursen M, Gelineck J, Eiskjaer SP, Thomsen K, Bunger CE Interobserver and intraobserver agreement of radiograph interpretation with and without pedicle screw implants: the need for a detailed classification system in posterolateral spinal fusion. Spine (Phila Pa 1976). 2001 Mar 1;26(5):538-43; discussion 543-4. doi: 10.1097/00007632-200103010-00018.
Chun DS, Baker KC, Hsu WK Lumbar pseudarthrosis: a review of current diagnosis and treatment. Neurosurg Focus. 2015 Oct;39(4):E10. doi: 10.3171/2015.7.FOCUS15292.
Cole CD, McCall TD, Schmidt MH, Dailey AT Comparison of low back fusion techniques: transforaminal lumbar interbody fusion (TLIF) or posterior lumbar interbody fusion (PLIF) approaches. Curr Rev Musculoskelet Med. 2009 Jun;2(2):118-26. doi: 10.1007/s12178-009-9053-8. Epub 2009 Apr 29.
Demir O, Oksuz E, Deniz FE, Demir O Assessing the effects of lumbar posterior stabilization and fusion to vertebral bone density in stabilized and adjacent segments by using Hounsfield unit. J Spine Surg. 2017 Dec;3(4):548-553. doi: 10.21037/jss.2017.09.05.
Fogel GR, Toohey JS, Neidre A, Brantigan JW Fusion assessment of posterior lumbar interbody fusion using radiolucent cages: X-ray films and helical computed tomography scans compared with surgical exploration of fusion. Spine J. 2008 Jul-Aug;8(4):570-7. doi: 10.1016/j.spinee.2007.03.013. Epub 2007 May 29.
Kim KS, Yang TK, Lee JC Radiological changes in the bone fusion site after posterior lumbar interbody fusion using carbon cages impacted with laminar bone chips: follow-up study over more than 4 years. Spine (Phila Pa 1976). 2005 Mar 15;30(6):655-60. doi: 10.1097/01.brs.0000155421.07796.7f.
Lee S, Chung CK, Oh SH, Park SB Correlation between Bone Mineral Density Measured by Dual-Energy X-Ray Absorptiometry and Hounsfield Units Measured by Diagnostic CT in Lumbar Spine. J Korean Neurosurg Soc. 2013 Nov;54(5):384-9. doi: 10.3340/jkns.2013.54.5.384. Epub 2013 Nov 30.
Martin BI, Mirza SK, Comstock BA, Gray DT, Kreuter W, Deyo RA Reoperation rates following lumbar spine surgery and the influence of spinal fusion procedures. Spine (Phila Pa 1976). 2007 Feb 1;32(3):382-7. doi: 10.1097/01.brs.0000254104.55716.46.
Mobbs RJ, Phan K, Malham G, Seex K, Rao PJ Lumbar interbody fusion: techniques, indications and comparison of interbody fusion options including PLIF, TLIF, MI-TLIF, OLIF/ATP, LLIF and ALIF. J Spine Surg. 2015 Dec;1(1):2-18. doi: 10.3978/j.issn.2414-469X.2015.10.05.
Nguyen HS, Shabani S, Patel M, Maiman D Posterolateral lumbar fusion: Relationship between computed tomography Hounsfield units and symptomatic pseudoarthrosis. Surg Neurol Int. 2015 Nov 25;6(Suppl 24):S611-4. doi: 10.4103/2152-7806.170443. eCollection 2015.
Sakeb N, Ahsan K Comparison of the early results of transforaminal lumbar interbody fusion and posterior lumbar interbody fusion in symptomatic lumbar instability. Indian J Orthop. 2013 May;47(3):255-63. doi: 10.4103/0019-5413.111484.
Schreiber JJ, Anderson PA, Hsu WK Use of computed tomography for assessing bone mineral density. Neurosurg Focus. 2014;37(1):E4. doi: 10.3171/2014.5.FOCUS1483.
Schreiber JJ, Anderson PA, Rosas HG, Buchholz AL, Au AG Hounsfield units for assessing bone mineral density and strength: a tool for osteoporosis management. J Bone Joint Surg Am. 2011 Jun 1;93(11):1057-63. doi: 10.2106/JBJS.J.00160.
Schreiber JJ, Hughes AP, Taher F, Girardi FP An association can be found between hounsfield units and success of lumbar spine fusion. HSS J. 2014 Feb;10(1):25-9. doi: 10.1007/s11420-013-9367-3. Epub 2013 Nov 1.
Spruit M, Meijers H, Obradov M, Anderson PG CT density measurement of bone graft within an intervertebral lumbar cage: increase of hounsfield units as an indicator for increasing bone mineral content. J Spinal Disord Tech. 2004 Jun;17(3):232-5. doi: 10.1097/00024720-200406000-00011.
Williams AL, Gornet MF, Burkus JK CT evaluation of lumbar interbody fusion: current concepts. AJNR Am J Neuroradiol. 2005 Sep;26(8):2057-66. No abstract available.
Prospective Hounsfield Unit Measurements of Intercorporal Bone Grafts Remodelling Towards Spinal Fusion
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