Spinal Cord Injury — Resistance Training and Testosterone After Spinal Cord Injury
Citation(s)
Abilmona SM, Gorgey AS Associations of the trunk skeletal musculature and dietary intake to biomarkers of cardiometabolic health after spinal cord injury. Clin Physiol Funct Imaging. 2018 Feb 6. doi: 10.1111/cpf.12505. [Epub ahead of print]
Gorgey AS, Caudill C, Khalil RE Effects of once weekly NMES training on knee extensors fatigue and body composition in a person with spinal cord injury. J Spinal Cord Med. 2016;39(1):99-102. doi: 10.1179/2045772314Y.0000000293. Epub 2015 Jan 23.
Gorgey AS, Cirnigliaro CM, Bauman WA, Adler RA Estimates of the precision of regional and whole body composition by dual-energy x-ray absorptiometry in persons with chronic spinal cord injury. Spinal Cord. 2018 Mar 6. doi: 10.1038/s41393-018-0079-x. [Epub ahead of print]
Gorgey AS, Dolbow DR, Cifu DX, Gater DR Neuromuscular electrical stimulation attenuates thigh skeletal muscles atrophy but not trunk muscles after spinal cord injury. J Electromyogr Kinesiol. 2013 Aug;23(4):977-84. doi: 10.1016/j.jelekin.2013.04.007. Epub 2013 May 15.
Gorgey AS, Lester RM, Wade RC, Khalil RE, Khan RK, Anderson ML, Castillo T A feasibility pilot using telehealth videoconference monitoring of home-based NMES resistance training in persons with spinal cord injury. Spinal Cord Ser Cases. 2017 Jun 29;3:17039. doi: 10.1038/scsandc.2017.39. eCollection 2017.
Gorgey AS, Mather KJ, Cupp HR, Gater DR Effects of resistance training on adiposity and metabolism after spinal cord injury. Med Sci Sports Exerc. 2012 Jan;44(1):165-74. doi: 10.1249/MSS.0b013e31822672aa.
Gorgey AS, Moore PD, Wade RC, Gill RS, Lavis T, Adler RA Disruption in bone marrow fat may attenuate testosterone action on muscle size after spinal cord injury: a case report. Eur J Phys Rehabil Med. 2017 Aug;53(4):625-629. doi: 10.23736/S1973-9087.17.04452-5. Epub 2017 Mar 13.
Gorgey AS, Shepherd C Skeletal muscle hypertrophy and decreased intramuscular fat after unilateral resistance training in spinal cord injury: case report. J Spinal Cord Med. 2010;33(1):90-5.
McCauley LS, Sumrell RM, Gorgey AS Anthropometric Prediction of Visceral Adipose Tissue in Persons With Motor Complete Spinal Cord Injury. PM R. 2018 Feb 21. pii: S1934-1482(18)30098-4. doi: 10.1016/j.pmrj.2018.02.007. [Epub ahead of print]
Moore PD, Gorgey AS, Wade RC, Khalil RE, Lavis TD, Khan R, Adler RA Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cord injury: A case series. World J Clin Cases. 2016 Jul 16;4(7):172-6. doi: 10.12998/wjcc.v4.i7.172.
Nightingale TE, Gorgey AS Predicting Basal Metabolic Rate in Men with Motor Complete Spinal Cord Injury. Med Sci Sports Exerc. 2018 Jan 8. doi: 10.1249/MSS.0000000000001548. [Epub ahead of print]
O'Brien LC, Chen Q, Savas J, Lesnefsky EJ, Gorgey AS Skeletal muscle mitochondrial mass is linked to lipid and metabolic profile in individuals with spinal cord injury. Eur J Appl Physiol. 2017 Nov;117(11):2137-2147. doi: 10.1007/s00421-017-3687-9. Epub
O'Brien LC, Graham ZA, Chen Q, Lesnefsky EJ, Cardozo C, Gorgey AS Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury. Spinal Cord. 2018 Mar 20. doi: 10.1038/s41393-018-0089-8. [Epub ahead of print]
Rankin KC, O'Brien LC, Gorgey AS Quantification of trunk and android lean mass using dual energy x-ray absorptiometry compared to magnetic resonance imaging after spinal cord injury. J Spinal Cord Med. 2018 Feb 20:1-9. doi: 10.1080/10790268.2018.1438879. [Epub ahead of print]
Rankin KC, O'Brien LC, Segal L, Khan MR, Gorgey AS Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. Biomed Res Int. 2017;2017:1364818. doi: 10.1155/2017/1364818. Epub 2017 Aug 30.
Wade RC, Gorgey AS Anthropometric prediction of skeletal muscle cross-sectional area in persons with spinal cord injury. J Appl Physiol (1985). 2017 May 1;122(5):1255-1261. doi: 10.1152/japplphysiol.01042.2016. Epub 2017 Mar 2.
Effects of Evoked Resistance Training and Testosterone After Spinal Cord Injury
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
