Spinal Cord Injuries — Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
Citation(s)
Alibeji NA, Kirsch NA, Sharma N A Muscle Synergy-Inspired Adaptive Control Scheme for a Hybrid Walking Neuroprosthesis. Front Bioeng Biotechnol. 2015 Dec 21;3:203. doi: 10.3389/fbioe.2015.00203. eCollection 2015. Review.
Alibeji NA, Molazadeh V, Dicianno BE, Sharma N A Control Scheme That Uses Dynamic Postural Synergies to Coordinate a Hybrid Walking Neuroprosthesis: Theory and Experiments. Front Neurosci. 2018 Apr 10;12:159. doi: 10.3389/fnins.2018.00159. eCollection 2018.
Bao X, Kirsch N, Dodson A, Sharma N Model Predictive Control of a Feedback-Linearized Hybrid Neuroprosthetic System With a Barrier Penalty. J Comput Nonlinear Dyn. 2019 Oct 1;14(10):101009-1010097. doi: 10.1115/1.4042903. Epub 2019 Sep 9.
Kirsch N, Alibeji N, Fisher L, Gregory C, Sharma N A semi-active hybrid neuroprosthesis for restoring lower limb function in paraplegics. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:2557-60. doi: 10.1109/EMBC.2014.6944144.
Kirsch NA, Bao X, Alibeji NA, Dicianno BE, Sharma N Model-Based Dynamic Control Allocation in a Hybrid Neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng. 2018 Jan;26(1):224-232. doi: 10.1109/TNSRE.2017.2756023. Epub 2017 Sep 22.
Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
