Skin Condition — Rice Ceramide Supplementation and Skin Health
Citation(s)
Asai S, Miyachi H [Evaluation of skin-moisturizing effects of oral or percutaneous use of plant ceramides]. Rinsho Byori. 2007 Mar;55(3):209-15. Japanese.
Guillou S, Ghabri S, Jannot C, Gaillard E, Lamour I, Boisnic S The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. Int J Cosmet Sci. 2011 Apr;33(2):138-43. doi: 10.1111/j.1468-2
Kawano K, Umemura K Oral intake of beet extract provides protection against skin barrier impairment in hairless mice. Phytother Res. 2013 May;27(5):775-83. doi: 10.1002/ptr.4792. Epub 2012 Sep 4.
Kimata H Improvement of atopic dermatitis and reduction of skin allergic responses by oral intake of konjac ceramide. Pediatr Dermatol. 2006 Jul-Aug;23(4):386-9.
Yeom M, Kim SH, Lee B, Han JJ, Chung GH, Choi HD, Lee H, Hahm DH Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. J Dermatol Sci. 2012 Aug;67(2):101-10. doi: 10.1016/j.jdermsci.2012.05.009. Epub 2012 Jun 7.
The Effects of Rice Ceramide Supplementation in Improving Skin Health
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
