Schizophrenia — Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation
Citation(s)
Andreasen NC, Arndt S, Miller D, Flaum M, Nopoulos P Correlational studies of the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms: an overview and update. Psychopathology. 1995;28(1):7-17. Review.
Andreasen NC The Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. Br J Psychiatry Suppl. 1989 Nov;(7):49-58. Review.
Antal A, Paulus W Transcranial alternating current stimulation (tACS). Front Hum Neurosci. 2013 Jun 28;7:317. doi: 10.3389/fnhum.2013.00317. Print 2013.
Bokil H, Andrews P, Kulkarni JE, Mehta S, Mitra PP Chronux: a platform for analyzing neural signals. J Neurosci Methods. 2010 Sep 30;192(1):146-51. doi: 10.1016/j.jneumeth.2010.06.020. Epub 2010 Jul 15.
Cohen J A power primer. Psychol Bull. 1992 Jul;112(1):155-9.
Delorme A, Makeig S EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods. 2004 Mar 15;134(1):9-21.
Dmochowski JP, Koessler L, Norcia AM, Bikson M, Parra LC Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation. Neuroimage. 2017 Aug 15;157:69-80. doi: 10.1016/j.neuroimage.2017.05.059. Epub 2017 May 31.
Drewes J, VanRullen R This is the rhythm of your eyes: the phase of ongoing electroencephalogram oscillations modulates saccadic reaction time. J Neurosci. 2011 Mar 23;31(12):4698-708. doi: 10.1523/JNEUROSCI.4795-10.2011.
Kasten FH, Herrmann CS Transcranial Alternating Current Stimulation (tACS) Enhances Mental Rotation Performance during and after Stimulation. Front Hum Neurosci. 2017 Jan 31;11:2. doi: 10.3389/fnhum.2017.00002. eCollection 2017.
Moritz S, Woodward TS Jumping to conclusions in delusional and non-delusional schizophrenic patients. Br J Clin Psychol. 2005 Jun;44(Pt 2):193-207.
Moritz S, Woodward TS Metacognitive training in schizophrenia: from basic research to knowledge translation and intervention. Curr Opin Psychiatry. 2007 Nov;20(6):619-25. Review.
Moritz, S , Veckenstedt, R., Vitzthuma, F., Köthera, U., & Woodward,T.S., Metacognitive training in schizophrenia. Theoretical rationale and administration, in Social Cognition In Schizophrenia: From Evidence to Treatment, David L. Roberts and D.L. Penn, Editors. 2013, Oxford University Press: Oxford. p. 358-383.
Rjosk V, Kaminski E, Hoff M, Gundlach C, Villringer A, Sehm B, Ragert P Transcranial Alternating Current Stimulation at Beta Frequency: Lack of Immediate Effects on Excitation and Interhemispheric Inhibition of the Human Motor Cortex. Front Hum Neurosci. 2016 Nov 3;10:560. eCollection 2016.
Sanford N, Lecomte T, Leclerc C, Wykes T, Woodward TS Change in jumping to conclusions linked to change in delusions in early psychosis. Schizophr Res. 2013 Jun;147(1):207-208. doi: 10.1016/j.schres.2013.02.042. Epub 2013 Apr 3.
Speechley WJ, Whitman JC, Woodward TS The contribution of hypersalience to the "jumping to conclusions" bias associated with delusions in schizophrenia. J Psychiatry Neurosci. 2010 Jan;35(1):7-17.
Vosskuhl J, Strüber D, Herrmann CS Non-invasive Brain Stimulation: A Paradigm Shift in Understanding Brain Oscillations. Front Hum Neurosci. 2018 May 25;12:211. doi: 10.3389/fnhum.2018.00211. eCollection 2018. Review.
Whitman JC, Ward LM, Woodward TS Patterns of Cortical Oscillations Organize Neural Activity into Whole-Brain Functional Networks Evident in the fMRI BOLD Signal. Front Hum Neurosci. 2013 Mar 14;7:80. doi: 10.3389/fnhum.2013.00080. eCollection 2013.
Woodward TS, Munz M, LeClerc C, Lecomte T Change in delusions is associated with change in "jumping to conclusions". Psychiatry Res. 2009 Dec 30;170(2-3):124-7. doi: 10.1016/j.psychres.2008.10.020. Epub 2009 Nov 10.
Zaehle T, Rach S, Herrmann CS Transcranial alternating current stimulation enhances individual alpha activity in human EEG. PLoS One. 2010 Nov 1;5(11):e13766. doi: 10.1371/journal.pone.0013766.
Zhang C, Paolozza A, Tseng PH, Reynolds JN, Munoz DP, Itti L Detection of Children/Youth With Fetal Alcohol Spectrum Disorder Through Eye Movement, Psychometric, and Neuroimaging Data. Front Neurol. 2019 Feb 18;10:80. doi: 10.3389/fneur.2019.00080. eCollection 2019.
Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
