NCT05880303 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Lee YH, Baharuddin NA, Chan SW, Rahman MT, Bartold PM, Sockalingam S, Vaithilingam RD
Localisation of citrullinated and carbamylated proteins in inflamed gingival tissues from rheumatoid arthritis patients. Clin Oral Investig. 2021 Mar;25(3):1441-1450. doi: 10.1007/s00784-020-03452-9. Epub 2020 Jul 12.
Lee YH, Lew PH, Cheah CW, Rahman MT, Baharuddin NA, Vaithilingam RD
Potential mechanisms linking periodontitis to rheumatoid arthritis. J Int Acad Periodontol. 2019 Jul 1;21(3):99-110.
Lew PH, Rahman MT, Safii SH, Baharuddin NA, Bartold PM, Sockalingam S, Kassim NLA, Vaithilingam RD
Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study. BMC Oral Health. 2021 Jul 20;21(1):360. doi: 10.1186/s12903-021-01712-y.

Effect of Nonsurgical Periodontal Therapy (NSPT) on Inflammatory Mediators, Subgingival Microbiota and Quality of Life Impacts in Rheumatoid Arthritis Subjects With Periodontitis

Details for clinical trial NCT05880303

Clinical trial NCT05880303 - References