Rehabilitation — Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia
Citation(s)
Bertelli JA, Ghizoni MF Nerve transfers for elbow and finger extension reconstruction in midcervical spinal cord injuries. J Neurosurg. 2015 Jan;122(1):121-7. doi: 10.3171/2014.8.JNS14277.
Bertelli JA, Tacca CP, Ghizoni MF, Kechele PR, Santos MA Transfer of supinator motor branches to the posterior interosseous nerve to reconstruct thumb and finger extension in tetraplegia: case report. J Hand Surg Am. 2010 Oct;35(10):1647-51. doi: 10.1016/j.jhsa.2010.07.012.
Bunketorp-Kall L, Wangdell J, Reinholdt C, Friden J Satisfaction with upper limb reconstructive surgery in individuals with tetraplegia: the development and reliability of a Swedish self-reported satisfaction questionnaire. Spinal Cord. 2017 Jul;55(7):664-671. doi: 10.1038/sc.2017.12. Epub 2017 Feb 21.
Friden J, Gohritz A Tetraplegia Management Update. J Hand Surg Am. 2015 Dec;40(12):2489-500. doi: 10.1016/j.jhsa.2015.06.003.
Friden J, Lieber RL Reach out and grasp the opportunity: reconstructive hand surgery in tetraplegia. J Hand Surg Eur Vol. 2019 May;44(4):343-353. doi: 10.1177/1753193419827814. Epub 2019 Feb 11.
Friden J, Reinholdt C, Turcsanyii I, Gohritz A A single-stage operation for reconstruction of hand flexion, extension, and intrinsic function in tetraplegia: the alphabet procedure. Tech Hand Up Extrem Surg. 2011 Dec;15(4):230-5. doi: 10.1097/BTH.0b013e31821b5896.
Moberg E The present state of surgical rehabilitation of the upper limb in tetraplegia. Paraplegia. 1987 Aug;25(4):351-6. doi: 10.1038/sc.1987.63. No abstract available.
Wangdell J, Bunketorp-Kall L, Koch-Borner S, Friden J Early Active Rehabilitation After Grip Reconstructive Surgery in Tetraplegia. Arch Phys Med Rehabil. 2016 Jun;97(6 Suppl):S117-25. doi: 10.1016/j.apmr.2015.09.025.
Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
