Bursch B, Beezy J, Shaw R Emergency department satisfaction: what matters most? Ann Emerg Med. 1993 Mar;22(3):586-91.
Casarett D, Karlawish JH, Sugarman J Determining when quality improvement initiatives should be considered research: proposed criteria and potential implications. JAMA. 2000 May 3;283(17):2275-80.
Choung W, Heinrich SD Acute annular ligament interposition into the radiocapitellar joint in children (nursemaid's elbow). J Pediatr Orthop. 1995 Jul-Aug;15(4):454-6.
Donner A, Donald A The statistical analysis of multiple binary measurements. J Clin Epidemiol. 1988;41(9):899-905.
Fry M, Holdgate A Nurse-initiated intravenous morphine in the emergency department: efficacy, rate of adverse events and impact on time to analgesia. Emerg Med (Fremantle). 2002 Sep;14(3):249-54.
Illingworth CM Pulled elbow: a study of 100 patients. Br Med J. 1975 Jun 21;2(5972):672-4.
Jongschaap HC, Youngson GG, Beattie TF The epidemiology of radial head subluxation ('pulled elbow') in the Aberdeen city area. Health Bull (Edinb). 1990 Mar;48(2):58-61.
Kaplan RE, Lillis KA Recurrent nursemaid's elbow (annular ligament displacement) treatment via telephone. Pediatrics. 2002 Jul;110(1 Pt 1):171-4.
Kerry SM, Bland JM Analysis of a trial randomised in clusters. BMJ. 1998 Jan 3;316(7124):54.
Macias CG, Bothner J, Wiebe R A comparison of supination/flexion to hyperpronation in the reduction of radial head subluxations. Pediatrics. 1998 Jul;102(1):e10.
Macias CG, Wiebe R, Bothner J History and radiographic findings associated with clinically suspected radial head subluxations. Pediatr Emerg Care. 2000 Feb;16(1):22-5.
Moser MS, Abu-Laban RB, van Beek CA Attitude of emergency department patients with minor problems to being treated by a nurse practitioner. CJEM. 2004 Jul;6(4):246-52.
Newcombe RG Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med. 1998 Apr 30;17(8):873-90. Erratum in: Stat Med 1999 May 30;18(10):1293.
O'Brien PC, Fleming TR A multiple testing procedure for clinical trials. Biometrics. 1979 Sep;35(3):549-56.
Salt P, Clancy M Implementation of the Ottawa Ankle Rules by nurses working in an accident and emergency department. J Accid Emerg Med. 1997 Nov;14(6):363-5.
Salter RB, Zaltz C Anatomic investigations of the mechanism of injury and pathologic anatomy of "pulled elbow" in young children. Clin Orthop Relat Res. 1971;77:134-43.
Schunk JE Radial head subluxation: epidemiology and treatment of 87 episodes. Ann Emerg Med. 1990 Sep;19(9):1019-23.
Schutzman SA, Teach S Upper-extremity impairment in young children. Ann Emerg Med. 1995 Oct;26(4):474-9.
Snyder HS Radiographic changes with radial head subluxation in children. J Emerg Med. 1990 May-Jun;8(3):265-9. Erratum in: J Emerg Med 1990 Nov-Dec;8(6):775, 805.
Taha AM The treatment of pulled elbow: a prospective randomized study. Arch Orthop Trauma Surg. 2000;120(5-6):336-7.
Tambimuttu J, Hawley R, Marshall A Nurse-initiated x-ray of isolated limb fractures in the emergency department: research outcomes and future directions. Aust Crit Care. 2002 Aug;15(3):119-22. Review.
Teach SJ, Schutzman SA Prospective study of recurrent radial head subluxation. Arch Pediatr Adolesc Med. 1996 Feb;150(2):164-6.
Toupin P, Osmond MH, Correll R, Plint A Radial head subluxation: how long do children wait in the emergency department before reduction? CJEM. 2007 Sep;9(5):333-7.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.