Clinical trial NCT03096444 - References

Pruritus — Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

Citation(s)

•   Abels C
  Intra-epidermal nerve fibres in human skin: back to the roots. Exp Dermatol. 2014 Apr;23(4):232-3. doi: 10.1111/exd.12326. Epub 2014 Feb 16.
•   Andersen HH, Sørensen AR, Nielsen GA, Mølgaard MS, Stilling P, Boudreau SA, Elberling J, Arendt-Nielsen L
  A Test-Retest Reliability Study of Human Experimental Models of Histaminergic and Non-histaminergic Itch. Acta Derm Venereol. 2017 Feb 8;97(2):198-207. doi: 10.2340/00015555-2502.
•   Brenaut E, Garlantezec R, Talour K, Misery L
  Itch characteristics in five dermatoses: non-atopic eczema, atopic dermatitis, urticaria, psoriasis and scabies. Acta Derm Venereol. 2013 Sep 4;93(5):573-4. doi: 10.2340/00015555-1599.
•   Carlton SM, Coggeshall RE
  Inflammation-induced changes in peripheral glutamate receptor populations. Brain Res. 1999 Feb 27;820(1-2):63-70.
•   Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB Jr, Manuel JC
  The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005 May-Jun;22(3):192-9. Review.
•   Coggeshall RE, Carlton SM
  Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery. J Comp Neurol. 1998 Feb 2;391(1):78-86.
•   Davidson EM, Coggeshall RE, Carlton SM
  Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. Neuroreport. 1997 Mar 3;8(4):941-6.
•   Friedman PM, Mafong EA, Friedman ES, Geronemus RG
  Topical anesthetics update: EMLA and beyond. Dermatol Surg. 2001 Dec;27(12):1019-26.
•   Gammaitoni A, Gallagher RM, Welz-Bosna M
  Topical ketamine gel: possible role in treating neuropathic pain. Pain Med. 2000 Mar;1(1):97-100.
•   Gammaitoni AR, Alvarez NA, Galer BS
  Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature. J Clin Pharmacol. 2003 Feb;43(2):111-7. Review.
•   Gerner P, Kao G, Srinivasa V, Narang S, Wang GK
  Topical amitriptyline in healthy volunteers. Reg Anesth Pain Med. 2003 Jul-Aug;28(4):289-93.
•   Griffin JR, Davis MD
  Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster. J Drugs Dermatol. 2015 Feb;14(2):115-8.
•   Hoeck EA, Marker JB, Gazerani P, H Andersen H, Arendt-Nielsen L
  Preclinical and human surrogate models of itch. Exp Dermatol. 2016 Oct;25(10):750-7. doi: 10.1111/exd.13078. Review.
•   Jackson D, Chen AH, Bennett CR
  Identifying true lidocaine allergy. J Am Dent Assoc. 1994 Oct;125(10):1362-6.
•   Kopsky DJ, Keppel Hesselink JM, Bhaskar A, Hariton G, Romanenko V, Casale R
  Analgesic effects of topical ketamine. Minerva Anestesiol. 2015 Apr;81(4):440-9. Epub 2014 May 22. Review.
•   LaMotte RH, Dong X, Ringkamp M
  Sensory neurons and circuits mediating itch. Nat Rev Neurosci. 2014 Jan;15(1):19-31. doi: 10.1038/nrn3641. Review.
•   LaMotte RH, Shimada SG, Green BG, Zelterman D
  Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage. J Neurophysiol. 2009 Mar;101(3):1430-43. doi: 10.1152/jn.91268.2008. Epub 2009 Jan 14.
•   Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I
  Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. J Neurophysiol. 2007 Jan;97(1):415-22. Epub 2006 Aug 16.
•   Lynch ME, Clark AJ, Sawynok J, Sullivan MJ
  Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 2005 Jul;103(1):140-6.
•   Lynch ME, Clark AJ, Sawynok J, Sullivan MJ
  Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. J Pain. 2005 Oct;6(10):644-9.
•   Lynch ME, Clark AJ, Sawynok J
  A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. Clin J Pain. 2003 Sep-Oct;19(5):323-8.
•   Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Uçeyler N, Valet M, Wasner G, Treede RD
  Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 2010 Sep;150(3):439-50. doi: 10.1016/j.pain.2010.05.002.
•   Mainka T, Malewicz NM, Baron R, Enax-Krumova EK, Treede RD, Maier C
  Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Eur J Pain. 2016 Jan;20(1):116-29. doi: 10.1002/ejp.703. Epub 2015 Apr 8.
•   Matterne U, Apfelbacher CJ, Loerbroks A, Schwarzer T, Büttner M, Ofenloch R, Diepgen TL, Weisshaar E
  Prevalence, correlates and characteristics of chronic pruritus: a population-based cross-sectional study. Acta Derm Venereol. 2011 Oct;91(6):674-9. doi: 10.2340/00015555-1159.
•   Matterne U, Apfelbacher CJ, Vogelgsang L, Loerbroks A, Weisshaar E
  Incidence and determinants of chronic pruritus: a population-based cohort study. Acta Derm Venereol. 2013 Sep 4;93(5):532-7. doi: 10.2340/00015555-1572.
•   Mehta AK, Halder S, Khanna N, Tandon OP, Singh UR, Sharma KK
  Role of NMDA and opioid receptors in neuropathic pain induced by chronic constriction injury of sciatic nerve in rats. J Basic Clin Physiol Pharmacol. 2012;23(2):49-55. doi: 10.1515/jbcpp-2012-0003.
•   Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, Ringkamp M
  Separate peripheral pathways for pruritus in man. J Neurophysiol. 2008 Oct;100(4):2062-9. doi: 10.1152/jn.90482.2008. Epub 2008 Jun 18.
•   Papoiu AD, Coghill RC, Kraft RA, Wang H, Yosipovitch G
  A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch. Neuroimage. 2012 Feb 15;59(4):3611-23. doi: 10.1016/j.neuroimage.2011.10.099. Epub 2011 Nov 12.
•   Papoiu AD, Tey HL, Coghill RC, Wang H, Yosipovitch G
  Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch. PLoS One. 2011 Mar 14;6(3):e17786. doi: 10.1371/journal.pone.0017786.
•   Patel T, Yosipovitch G
  Therapy of pruritus. Expert Opin Pharmacother. 2010 Jul;11(10):1673-82. doi: 10.1517/14656566.2010.484420. Review.
•   Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA
  Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci. 2008 Apr 23;28(17):4331-5. doi: 10.1523/JNEUROSCI.0716-08.2008.
•   Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B
  Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006 Aug;123(3):231-43. Epub 2006 May 11. Erratum in: Pain. 2006 Nov;125(1-2):197.
•   Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD
  Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain. 2006 Jan;10(1):77-88.
•   Sandroni P, Davis MD
  Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option? Arch Dermatol. 2006 Mar;142(3):283-6.
•   Sawynok J
  Topical analgesics for neuropathic pain in the elderly: current and future prospects. Drugs Aging. 2014 Dec;31(12):853-62. doi: 10.1007/s40266-014-0218-9. Review.
•   Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE
  Specific C-receptors for itch in human skin. J Neurosci. 1997 Oct 15;17(20):8003-8.
•   Selcuk E, Ertürk S, Afrashi A
  An adverse reaction to local anaesthesia: report of a case. Dent Update. 1996 Oct;23(8):345-6. Review.
•   Sikand P, Shimada SG, Green BG, LaMotte RH
  Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain. 2011 Nov;152(11):2485-94. doi: 10.1016/j.pain.2011.06.001. Epub 2011 Jul 29.
•   Sikand P, Shimada SG, Green BG, LaMotte RH
  Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain. 2009 Jul;144(1-2):66-75. doi: 10.1016/j.pain.2009.03.001. Epub 2009 May 6.
•   Ständer S, Schmelz M
  Chronic itch and pain--similarities and differences. Eur J Pain. 2006 Jul;10(5):473-8. Epub 2006 May 5. Review.
•   Sullivan RW, Ryzewski M, Holland MG, Marraffa JM
  Compounded ointment results in severe toxicity in a pediatric patient. Pediatr Emerg Care. 2013 Nov;29(11):1220-2. doi: 10.1097/PEC.0b013e3182aa4748.
•   Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G
  A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998 Feb;101(2):E1.
•   Tam E, Furlan AD
  Transdermal lidocaine and ketamine for neuropathic pain: a study of effectiveness and tolerability. Open Neurol J. 2012;6:58-64. doi: 10.2174/1874205X01206010058. Epub 2012 Jun 28.
•   Tandon OP, Mehta AK, Halder S, Khanna N, Sharma KK
  Peripheral interaction of opioid and NMDA receptors in inflammatory pain in rats. Indian J Physiol Pharmacol. 2010 Jan-Mar;54(1):21-31.
•   Tey HL, Yosipovitch G
  Targeted treatment of pruritus: a look into the future. Br J Dermatol. 2011 Jul;165(1):5-17. doi: 10.1111/j.1365-2133.2011.10217.x. Epub 2011 May 30. Review.
•   Uzaraga I, Gerbis B, Holwerda E, Gillis D, Wai E
  Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study. Support Care Cancer. 2012 Jul;20(7):1515-24. doi: 10.1007/s00520-011-1240-7. Epub 2011 Aug 17.
•   Wahlgren CF
  Itch and atopic dermatitis: an overview. J Dermatol. 1999 Nov;26(11):770-9. Review.
•   Weisshaar E, Gieler U, Kupfer J, Furue M, Saeki H, Yosipovitch G; International Forum on the Study of Itch
  Questionnaires to assess chronic itch: a consensus paper of the special interest group of the International Forum on the Study of Itch. Acta Derm Venereol. 2012 Sep;92(5):493-6. doi: 10.2340/00015555-1402.
•   Zhou S, Bonasera L, Carlton SM
  Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats. Neuroreport. 1996 Mar 22;7(4):895-900.
•   Zylka MJ, Rice FL, Anderson DJ
  Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005 Jan 6;45(1):17-25.

Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

Details for clinical trial NCT03096444