Baghurst KI, Crawford DA, Worsley A, Record SJ The Victorian Nutrition Survey--intakes and sources of dietary fats and cholesterol in the Victorian population. Med J Aust. 1988 Jul 4;149(1):12-5, 18-20.
Cook LS, Goldoft M, Schwartz SM, Weiss NS Incidence of adenocarcinoma of the prostate in Asian immigrants to the United States and their descendants. J Urol. 1999 Jan;161(1):152-5.
Culp BR, Titus BG, Lands WE Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandins Med. 1979 Nov;3(5):269-78.
Donaghy AJ, Baxter RC Insulin-like growth factor bioactivity and its modification in growth hormone resistant states. Baillieres Clin Endocrinol Metab. 1996 Jul;10(3):421-46. Review.
Feldman JM, Hilf R A role of estrogens and insulin binding in the dietary lipid alteration of R3230AC mammary carcinoma growth in rats. Cancer Res. 1985 May;45(5):1964-72.
Grimberg A, Cohen P Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol. 2000 Apr;183(1):1-9. Review.
Hwang D, Scollard D, Byrne J, Levine E Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst. 1998 Mar 18;90(6):455-60.
Kaplan PJ, Mohan S, Cohen P, Foster BA, Greenberg NM The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Cancer Res. 1999 May 1;59(9):2203-9.
Karmali RA Eicosanoids in neoplasia. Prev Med. 1987 Jul;16(4):493-502.
Kobayashi M, Sasaki S, Hamada GS, Tsugane S Serum n-3 fatty acids, fish consumption and cancer mortality in six Japanese populations in Japan and Brazil. Jpn J Cancer Res. 1999 Sep;90(9):914-21.
Marnett LJ Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates. Environ Health Perspect. 1990 Aug;88:5-12. Review.
Muir CS, Nectoux J, Staszewski J The epidemiology of prostatic cancer. Geographical distribution and time-trends. Acta Oncol. 1991;30(2):133-40. Review.
Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord. 1997 May;21(5):355-9.
Norrish AE, Jackson RT, McRae CU Non-steroidal anti-inflammatory drugs and prostate cancer progression. Int J Cancer. 1998 Aug 12;77(4):511-5.
Rose DP, Cohen LA Effects of dietary menhaden oil and retinyl acetate on the growth of DU 145 human prostatic adenocarcinoma cells transplanted into athymic nude mice. Carcinogenesis. 1988 Apr;9(4):603-5.
Rose DP, Connolly JM Dietary fat, fatty acids and prostate cancer. Lipids. 1992 Oct;27(10):798-803. Review.
Rose DP, Connolly JM Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. Prostate. 1991;18(3):243-54.
Shin BC, Ebner KE, Hudson BG, Carraway KL Membrane glycoprotein differences between normal lactating mammary tissue and the R3230 AC mammary tumor. Cancer Res. 1975 May;35(5):1135-40.
Stellman SD, Wang QS Cancer mortality in Chinese immigrants to New York City. Comparison with Chinese in Tianjin and with United States-born whites. Cancer. 1994 Feb 15;73(4):1270-5.
Sugano M, Hirahara F Polyunsaturated fatty acids in the food chain in Japan. Am J Clin Nutr. 2000 Jan;71(1 Suppl):189S-96S. doi: 10.1093/ajcn/71.1.189S. Review.
Tsujii M, Kawano S, DuBois RN Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3336-40.
Yu H, Rohan T Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000 Sep 20;92(18):1472-89. Review.
Zhou JR, Blackburn GL Bridging animal and human studies: what are the missing segments in dietary fat and prostate cancer? Am J Clin Nutr. 1997 Dec;66(6 Suppl):1572S-1580S. doi: 10.1093/ajcn/66.6.1572S. Review.
Comparison Study of a Low-Fat Diet Supplemented With Fish Oil and a Standard Western Diet in Individuals With Prostate Cancer
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.