Clinical trial NCT05142735 - References

Prodromal Schizophrenia — Effects of NAC on Symptoms of CHR Patients

Citation(s)

•   Addington J, Addington D, Abidi S, Raedler T, Remington G
  Canadian Treatment Guidelines for Individuals at Clinical High Risk of Psychosis. Can J Psychiatry. 2017 Sep;62(9):656-661. doi: 10.1177/0706743717719895. Epub 2017 Jul 21.
•   Atkinson RJ, Michie PT, Schall U
  Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis. Biol Psychiatry. 2012 Jan 15;71(2):98-104. doi: 10.1016/j.biopsych.2011.08.023. Epub 2011 Oct 13.
•   Breier A, Liffick E, Hummer TA, Vohs JL, Yang Z, Mehdiyoun NF, Visco AC, Metzler E, Zhang Y, Francis MM
  Effects of 12-month, double-blind N-acetyl cysteine on symptoms, cognition and brain morphology in early phase schizophrenia spectrum disorders. Schizophr Res. 2018 Sep;199:395-402. doi: 10.1016/j.schres.2018.03.012. Epub 2018 Mar 24.
•   Cabungcal JH, Counotte DS, Lewis E, Tejeda HA, Piantadosi P, Pollock C, Calhoon GG, Sullivan E, Presgraves E, Kil J, Hong LE, Cuenod M, Do KQ, O'Donnell P
  Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia. Neuron. 2014 Sep 3;83(5):1073-1084. doi: 10.1016/j.neuron.2014.07.028. Epub 2014 Aug 14.
•   Conus P, Seidman LJ, Fournier M, Xin L, Cleusix M, Baumann PS, Ferrari C, Cousins A, Alameda L, Gholam-Rezaee M, Golay P, Jenni R, Woo TW, Keshavan MS, Eap CB, Wojcik J, Cuenod M, Buclin T, Gruetter R, Do KQ
  N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis. Schizophr Bull. 2018 Feb 15;44(2):317-327. doi: 10.1093/schbul/sbx093.
•   Flatow J, Buckley P, Miller BJ
  Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry. 2013 Sep 15;74(6):400-9. doi: 10.1016/j.biopsych.2013.03.018. Epub 2013 May 15.
•   Hsieh MH, Shan JC, Huang WL, Cheng WC, Chiu MJ, Jaw FS, Hwu HG, Liu CC
  Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis. Schizophr Res. 2012 Sep;140(1-3):243-9. doi: 10.1016/j.schres.2012.06.021. Epub 2012 Jul 10.
•   Jahshan C, Cadenhead KS, Rissling AJ, Kirihara K, Braff DL, Light GA
  Automatic sensory information processing abnormalities across the illness course of schizophrenia. Psychol Med. 2012 Jan;42(1):85-97. doi: 10.1017/S0033291711001061. Epub 2011 Jul 11.
•   Kim M, Lee TH, Yoon YB, Lee TY, Kwon JS
  Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity. Schizophr Bull. 2018 Apr 6;44(3):575-583. doi: 10.1093/schbul/sbx102.
•   Lavoie S, Jack BN, Griffiths O, Ando A, Amminger P, Couroupis A, Jago A, Markulev C, McGorry PD, Nelson B, Polari A, Yuen HP, Whitford TJ
  Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further impairment with transition to psychosis. Schizophr Res. 2018 Jan;191:95-100. doi: 10.1016/j.schres.2017.11.005. Epub 2017 Nov 11.
•   Lepock JR, Ahmed S, Mizrahi R, Gerritsen CJ, Maheandiran M, Drvaric L, Bagby RM, Korostil M, Light GA, Kiang M
  Relationships between cognitive event-related brain potential measures in patients at clinical high risk for psychosis. Schizophr Res. 2020 Dec;226:84-94. doi: 10.1016/j.schres.2019.01.014. Epub 2019 Jan 22.
•   Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J, McFarlane W, Perkins DO, Pearlson GD, Woods SW
  Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull. 2003;29(4):703-15. doi: 10.1093/oxfordjournals.schbul.a007040. Erratum In: Schizophr Bull. 2004;30(2):following 217.
•   Nagai T, Tada M, Kirihara K, Yahata N, Hashimoto R, Araki T, Kasai K
  Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis. Schizophr Res. 2013 Nov;150(2-3):547-54. doi: 10.1016/j.schres.2013.08.005. Epub 2013 Sep 6.
•   Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH
  Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biol Psychiatry. 2014 Mar 15;75(6):459-69. doi: 10.1016/j.biopsych.2013.07.038. Epub 2013 Sep 16.
•   Schmidt SJ, Schultze-Lutter F, Schimmelmann BG, Maric NP, Salokangas RK, Riecher-Rossler A, van der Gaag M, Meneghelli A, Nordentoft M, Marshall M, Morrison A, Raballo A, Klosterkotter J, Ruhrmann S
  EPA guidance on the early intervention in clinical high risk states of psychoses. Eur Psychiatry. 2015 Mar;30(3):388-404. doi: 10.1016/j.eurpsy.2015.01.013. Epub 2015 Mar 3.
•   Sepehrmanesh Z, Heidary M, Akasheh N, Akbari H, Heidary M
  Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:289-296. doi: 10.1016/j.pnpbp.2017.11.001. Epub 2017 Nov 7.
•   Shaikh M, Valmaggia L, Broome MR, Dutt A, Lappin J, Day F, Woolley J, Tabraham P, Walshe M, Johns L, Fusar-Poli P, Howes O, Murray RM, McGuire P, Bramon E
  Reduced mismatch negativity predates the onset of psychosis. Schizophr Res. 2012 Jan;134(1):42-8. doi: 10.1016/j.schres.2011.09.022. Epub 2011 Oct 24.
•   Steullet P, Cabungcal JH, Monin A, Dwir D, O'Donnell P, Cuenod M, Do KQ
  Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? Schizophr Res. 2016 Sep;176(1):41-51. doi: 10.1016/j.schres.2014.06.021. Epub 2014 Jul 5.
•   Zheng W, Zhang QE, Cai DB, Yang XH, Qiu Y, Ungvari GS, Ng CH, Berk M, Ning YP, Xiang YT
  N-acetylcysteine for major mental disorders: a systematic review and meta-analysis of randomized controlled trials. Acta Psychiatr Scand. 2018 May;137(5):391-400. doi: 10.1111/acps.12862. Epub 2018 Feb 18.

Effects of N-acetylcysteine on Psychosis-like Symptoms and a Neurophysiological Biomarker of the Clinical High Risk for Schizophrenia

Details for clinical trial NCT05142735