NCT05198167 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Araújo MS, Santos MMPD, Silva CJA, Menezes RMP, Feijão AR, Medeiros SM
Prone positioning as an emerging tool in the care provided to patients infected with COVID-19: a scoping review. Rev Lat Am Enfermagem. 2021 Jan 8;29:e3397. doi: 10.1590/1518-8345.4732.3397. eCollection 2021. Review. English, Portuguese, Spanish.
Lima Serrano M, González Méndez MI, Carrasco Cebollero FM, Lima Rodríguez JS
Risk factors for pressure ulcer development in Intensive Care Units: A systematic review. Med Intensiva. 2017 Aug - Sep;41(6):339-346. doi: 10.1016/j.medin.2016.09.003. Epub 2016 Oct 22. Review. English, Spanish.
Perrillat A, Foletti JM, Lacagne AS, Guyot L, Graillon N
Facial pressure ulcers in COVID-19 patients undergoing prone positioning: How to prevent an underestimated epidemic? J Stomatol Oral Maxillofac Surg. 2020 Sep;121(4):442-444. doi: 10.1016/j.jormas.2020.06.008. Epub 2020 Jun 18.
Tayyib N, Coyer F, Lewis P
Saudi Arabian adult intensive care unit pressure ulcer incidence and risk factors: a prospective cohort study. Int Wound J. 2016 Oct;13(5):912-9. doi: 10.1111/iwj.12406. Epub 2015 Feb 9.
Tayyib N, Coyer F
Effectiveness of Pressure Ulcer Prevention Strategies for Adult Patients in Intensive Care Units: A Systematic Review. Worldviews Evid Based Nurs. 2016 Dec;13(6):432-444. doi: 10.1111/wvn.12177. Epub 2016 Oct 6. Review.
Why Prone? Why Now? Improving Outcomes for ARDS Patients
Crit Care Nurse. 2019 Oct;39(5):84. doi: 10.4037/ajcc2019878.

Efficacy of Hyperoxygenated Fatty Acids Versus Hydrocolloid Dressings in the Prevention of Pressure Ulcers in Critically Ill Prone Patients

Clinical trial NCT05198167 - References