Postural Tachycardia Syndrome — Peripheral Dopamine in Postural Tachycardia Syndrome
Citation(s)
Carey RM Theodore Cooper Lecture: Renal dopamine system: paracrine regulator of sodium homeostasis and blood pressure. Hypertension. 2001 Sep;38(3):297-302. Review.
Goldstein DS, Stull R, Eisenhofer G, Gill JR Jr Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans. Clin Sci (Lond). 1989 May;76(5):517-22.
Jose PA, Eisner GM, Felder RA Renal dopamine and sodium homeostasis. Curr Hypertens Rep. 2000 Apr;2(2):174-83. Review.
Kuchel O, Buu NT, Unger T Dopamine-sodium relationship: is dopamine a part of the endogenous natriuretic system? Contrib Nephrol. 1978;13:27-36.
Stokes GS, Monaghan JC, Pillai DN Effects of carbidopa and of intravenous saline infusion into normal and hypertensive subjects on urinary free and conjugated dopamine. J Hypertens. 1997 Jul;15(7):761-8.
Kidney Dopamine Effects on Urinary Sodium Excretion in Postural Tachycardia Syndrome
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