NCT01440712 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Abbas SM, Bissett IP, Parry BR
Meta-analysis of oral water-soluble contrast agent in the management of adhesive small bowel obstruction. Br J Surg. 2007 Apr;94(4):404-11. Review.
Biondo S, Parés D, Mora L, Martí Ragué J, Kreisler E, Jaurrieta E
Randomized clinical study of Gastrografin administration in patients with adhesive small bowel obstruction. Br J Surg. 2003 May;90(5):542-6.
Böhm B, Milsom JW, Fazio VW
Postoperative intestinal motility following conventional and laparoscopic intestinal surgery. Arch Surg. 1995 Apr;130(4):415-9.
Chen JH, Hsieh CB, Chao PC, Liu HD, Chen CJ, Liu YC, Yu JC
Effect of water-soluble contrast in colorectal surgery: a prospective randomized trial. World J Gastroenterol. 2005 May 14;11(18):2802-5.
Delaney CP, Wolff BG, Viscusi ER, Senagore AJ, Fort JG, Du W, Techner L, Wallin B
Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies. Ann Surg. 2007 Mar;245(3):355-63.
Holte K, Kehlet H
Postoperative ileus: a preventable event. Br J Surg. 2000 Nov;87(11):1480-93. Review.
Waldhausen JH, Schirmer BD
The effect of ambulation on recovery from postoperative ileus. Ann Surg. 1990 Dec;212(6):671-7.

Prospective Randomized Double Blind Study of the Effect of Gastrografin on Postoperative Ileus After Colorectal Surgery

Clinical trial NCT01440712 - References