NCT04482192 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Batra RK, Krishnan K, Agarwal A
Paravertebral block. J Anaesthesiol Clin Pharmacol. 2011 Jan;27(1):5-11.
Berrisford RG, Sabanathan SS
Direct access to the paravertebral space at thoracotomy. Ann Thorac Surg. 1990 May;49(5):854.
Elia N, Lysakowski C, Tramèr MR
Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of r
Fortier S, Hanna HA, Bernard A, Girard C
Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management. Eur J Anaesthesiol. 2012 N
Katayama T, Hirai S, Kobayashi R, Hamaishi M, Okada T, Mitsui N
Safety of the paravertebral block in patients ineligible for epidural block undergoing pulmonary resection. Gen Thorac Cardiovasc Surg. 2012 Dec;60(12):811-4. doi: 10.1007/s11748-012-0149-5.
Krakowski JC, Arora H
Con: Thoracic Epidural Block Is Not Superior to Paravertebral Blocks for Open Thoracic Surgery. J Cardiothorac Vasc Anesth. 2015 Dec;29(6):1720-2. doi: 10.1053/j.jvca.2015.06.012. Epub 2015 Jun 10. Review.
Sabanathan S, Smith PJ, Pradhan GN, Hashimi H, Eng JB, Mearns AJ
Continuous intercostal nerve block for pain relief after thoracotomy. Ann Thorac Surg. 1988 Oct;46(4):425-6.
Wojtys ME, Wasikowski J, Wójcik N, Wójcik J, Wasilewski P, Lisowski P, Grodzki T
Assessment of postoperative pain management and comparison of effectiveness of pain relief treatment involving paravertebral block and thoracic epidural analgesia in patient

Continuous Paravertebral Block by Intraoperative Direct Access Versus Systemic Analgesia for Postthoracotomy Pain Relief

Details for clinical trial NCT04482192

Clinical trial NCT04482192 - References