Portal Hypertension — Utility of EUS-elastography to Predict Portal Hypertension
Citation(s)
Bolognesi M, Boscato N Spleen and liver cirrhosis: relationship between spleen enlargement and portal hypertension in patients with liver cirrhosis. In: Chen TM, ed. New Developments in Liver Cirrhosis Research. Hauppauge, NY: Nova Science Publishers, 2006; 49-67.
Calvaruso V, Bronte F, Conte E, Simone F, Craxì A, Di Marco V Modified spleen stiffness measurement by transient elastography is associated with presence of large oesophageal varices in patients with compensated hepatitis C virus cirrhosis. J Viral Hepat
Castera L, Forns X, Alberti A Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol. 2008 May;48(5):835-47. doi: 10.1016/j.jhep.2008.02.008. Epub 2008 Feb 26. Review.
Dawwas MF, Taha H, Leeds JS, Nayar MK, Oppong KW Diagnostic accuracy of quantitative EUS elastography for discriminating malignant from benign solid pancreatic masses: a prospective, single-center study. Gastrointest Endosc. 2012 Nov;76(5):953-61. doi: 1
de Franchis R; Baveno VI Faculty Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015 Sep;63(3):743-52. doi: 10.1016/j.jhep.2015.05.022.
Faigel DO, Rosen HR, Sasaki A, Flora K, Benner K EUS in cirrhotic patients with and without prior variceal hemorrhage in comparison with noncirrhotic control subjects. Gastrointest Endosc. 2000 Oct;52(4):455-62.
Frey H [Realtime elastography. A new ultrasound procedure for the reconstruction of tissue elasticity]. Radiologe. 2003 Oct;43(10):850-5. German.
Garcia-Tsao G, Bosch J Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010 Mar 4;362(9):823-32. doi: 10.1056/NEJMra0901512. Review. Erratum in: N Engl J Med. 2011 Feb 3;364(5):490. Dosage error in article text.
Giunta M, Conte D, Fraquelli M Role of spleen elastography in patients with chronic liver diseases. World J Gastroenterol. 2016 Sep 21;22(35):7857-67. doi: 10.3748/wjg.v22.i35.7857. Review.
Hammoud GM, Ibdah JA Utility of endoscopic ultrasound in patients with portal hypertension. World J Gastroenterol. 2014 Oct 21;20(39):14230-6. doi: 10.3748/wjg.v20.i39.14230. Review.
Kassem AM, Salama ZA, Zakaria MS, Hassaballah M, Hunter MS Endoscopic ultrasonographic study of the azygos vein before and after endoscopic obliteration of esophagogastric varices by injection sclerotherapy. Endoscopy. 2000 Aug;32(8):630-4.
Kuddus RH, Nalesnik MA, Subbotin VM, Rao AS, Gandhi CR Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes--an important mechanism of increased endogenous levels of ET-1 in liver cirrhosis. J Hepatol. 2000 Nov;33(5):725-32.
Lee YT, Sung JJ, Yung MY, Yu AL, Chung SC Use of color Doppler EUS in assessing azygos blood flow for patients with portal hypertension. Gastrointest Endosc. 1999 Jul;50(1):47-52.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
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Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.