Clinical trial NCT03442088 - References

Plaque Psoriasis — Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast

Citation(s)

•   Ackermann C, Kavanaugh A
  Economic burden of psoriatic arthritis. Pharmacoeconomics. 2008;26(2):121-9. doi: 10.2165/00019053-200826020-00003.
•   Ancuta P, Liu KY, Misra V, Wacleche VS, Gosselin A, Zhou X, Gabuzda D
  Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics. 2009 Aug 27;10:403. doi: 10.1186/1471-2164-10-403.
•   Au L, Meisch JP, Das LM, Binko AM, Boxer RS, Wen AM, Steinmetz NF, Lu KQ
  Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol. 2015 Dec;135(12):2971-2981. doi: 10.1038/jid.2015.322. Epub 2015 Aug 19.
•   Auffray C, Sieweke MH, Geissmann F
  Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669-92. doi: 10.1146/annurev.immunol.021908.132557.
•   Benoit S, Toksoy A, Ahlmann M, Schmidt M, Sunderkotter C, Foell D, Pasparakis M, Roth J, Goebeler M
  Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis. Br J Dermatol. 2006 Jul;155(1):62-6. doi: 10.1111/j.1365-2133.2006.07198.x.
•   Blumenstein M, Boekstegers P, Fraunberger P, Andreesen R, Ziegler-Heitbrock HW, Fingerle-Rowson G
  Cytokine production precedes the expansion of CD14+CD16+ monocytes in human sepsis: a case report of a patient with self-induced septicemia. Shock. 1997 Jul;8(1):73-5. doi: 10.1097/00024382-199707000-00012.
•   Brunner PM, Koszik F, Reininger B, Kalb ML, Bauer W, Stingl G
  Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages. J Allergy Clin Immunol. 2013 Nov;132(5):1184-1193.e8. doi: 10.1016/j.jaci.2013.05.036. Epub 2013 Jul 26.
•   Cao LY, Soler DC, Debanne SM, Grozdev I, Rodriguez ME, Feig RL, Carman TL, Gilkeson RC, Orringer CE, Kern EF, McCormick TS, Cooper KD, Korman NJ
  Psoriasis and cardiovascular risk factors: increased serum myeloperoxidase and corresponding immunocellular overexpression by Cd11b(+) CD68(+) macrophages in skin lesions. Am J Transl Res. 2013 Dec 1;6(1):16-27. eCollection 2013.
•   Chaudhari U, Romano P, Mulcahy LD, Dooley LT, Baker DG, Gottlieb AB
  Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet. 2001 Jun 9;357(9271):1842-7. doi: 10.1016/s0140-6736(00)04954-0.
•   Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT
  CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis. Arthritis Res Ther. 2010;12(1):R14. doi: 10.1186/ar2915. Epub 2010 Jan 26.
•   Davidovici BB, Sattar N, Prinz J, Puig L, Emery P, Barker JN, van de Kerkhof P, Stahle M, Nestle FO, Girolomoni G, Krueger JG
  Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol. 2010 Jul;130(7):1785-96. doi: 10.1038/jid.2010.103. Epub 2010 May 6. Erratum In: J Invest Dermatol. 2010 Oct;130(10):2517. Jorg, Prinz C [corrected to Prinz, Jorg C].
•   Desai SB, Furst DE
  Problems encountered during anti-tumour necrosis factor therapy. Best Pract Res Clin Rheumatol. 2006 Aug;20(4):757-90. doi: 10.1016/j.berh.2006.06.002.
•   Feldman SR, Evans C, Russell MW
  Systemic treatment for moderate to severe psoriasis: estimates of failure rates and direct medical costs in a north-eastern US managed care plan. J Dermatolog Treat. 2005 Feb;16(1):37-42. doi: 10.1080/09546630510025941.
•   Fingerle G, Pforte A, Passlick B, Blumenstein M, Strobel M, Ziegler-Heitbrock HW
  The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients. Blood. 1993 Nov 15;82(10):3170-6.
•   Fowler JF, Duh MS, Rovba L, Buteau S, Pinheiro L, Lobo F, Sung J, Doyle JJ, Swensen A, Mallett DA, Kosicki G
  The impact of psoriasis on health care costs and patient work loss. J Am Acad Dermatol. 2008 Nov;59(5):772-80. doi: 10.1016/j.jaad.2008.06.043.
•   Funderburg NT, Zidar DA, Shive C, Lioi A, Mudd J, Musselwhite LW, Simon DI, Costa MA, Rodriguez B, Sieg SF, Lederman MM
  Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome. Blood. 2012 Nov 29;120(23):4599-608. doi: 10.1182/blood-2012-05-433946. Epub 2012 Oct 11.
•   Gallego C, Golenbock D, Gomez MA, Saravia NG
  Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis. Infect Immun. 2011 Jul;79(7):2871-9. doi: 10.1128/IAI.01388-10. Epub 2011 Apr 25.
•   Garcia-Rodriguez S, Arias-Santiago S, Perandres-Lopez R, Castellote L, Zumaquero E, Navarro P, Buendia-Eisman A, Ruiz JC, Orgaz-Molina J, Sancho J, M Zubiaur
  Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. J Eur Acad Dermatol Venereol. 2013 Feb;27(2):242-50. doi: 10.1111/j.1468-3083.2011.04372.x.
•   Geissmann F, Jung S, Littman DR
  Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003 Jul;19(1):71-82. doi: 10.1016/s1074-7613(03)00174-2.
•   Gelfand JM, Shin DB, Neimann AL, Wang X, Margolis DJ, Troxel AB
  The risk of lymphoma in patients with psoriasis. J Invest Dermatol. 2006 Oct;126(10):2194-201. doi: 10.1038/sj.jid.5700410. Epub 2006 Jun 1.
•   Golden JB, Groft SG, Squeri MV, Debanne SM, Ward NL, McCormick TS, Cooper KD
  Chronic Psoriatic Skin Inflammation Leads to Increased Monocyte Adhesion and Aggregation. J Immunol. 2015 Sep 1;195(5):2006-18. doi: 10.4049/jimmunol.1402307. Epub 2015 Jul 29.
•   Hanai H, Iida T, Takeuchi K, Watanabe F, Yamada M, Kikuyama M, Maruyama Y, Iwaoka Y, Hirayama K, Nagata S, Takai K
  Adsorptive depletion of elevated proinflammatory CD14+CD16+DR++ monocytes in patients with inflammatory bowel disease. Am J Gastroenterol. 2008 May;103(5):1210-6. doi: 10.1111/j.1572-0241.2007.01714.x. Epub 2008 Jan 2.
•   Hazard E, Cherry SB, Lalla D, Woolley JM, Wilfehrt H, Chiou CF
  Clinical and economic burden of psoriasis. Manag Care Interface. 2006 Apr;19(4):20-6.
•   Kim N, Thrash B, Menter A
  Comorbidities in psoriasis patients. Semin Cutan Med Surg. 2010 Mar;29(1):10-5. doi: 10.1016/j.sder.2010.01.002.
•   Kimball AB, Guerin A, Tsaneva M, Yu AP, Wu EQ, Gupta SR, Bao Y, Mulani PM
  Economic burden of comorbidities in patients with psoriasis is substantial. J Eur Acad Dermatol Venereol. 2011 Feb;25(2):157-63. doi: 10.1111/j.1468-3083.2010.03730.x. Epub 2010 Jun 17.
•   Kimball AB, Jacobson C, Weiss S, Vreeland MG, Wu Y
  The psychosocial burden of psoriasis. Am J Clin Dermatol. 2005;6(6):383-92. doi: 10.2165/00128071-200506060-00005.
•   Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl M; CNTO 1275 Psoriasis Study Group
  A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med. 2007 Feb 8;356(6):580-92. doi: 10.1056/NEJMoa062382.
•   Martinez FO
  The transcriptome of human monocyte subsets begins to emerge. J Biol. 2009;8(11):99. doi: 10.1186/jbiol206. Epub 2009 Dec 23.
•   Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM
  Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J. 2010 Apr;31(8):1000-6. doi: 10.1093/eurheartj/ehp567. Epub 2009 Dec 27.
•   Moniuszko M, Bodzenta-Lukaszyk A, Kowal K, Lenczewska D, Dabrowska M
  Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. Clin Immunol. 2009 Mar;130(3):338-46. doi: 10.1016/j.clim.2008.09.011. Epub 2008 Oct 25.
•   Mysliwska J, Smardzewski M, Marek-Trzonkowska N, Mysliwiec M, Raczynska K
  Expansion of CD14+CD16+ monocytes producing TNF-alpha in complication-free diabetes type 1 juvenile onset patients. Cytokine. 2012 Oct;60(1):309-17. doi: 10.1016/j.cyto.2012.03.010. Epub 2012 Apr 7.
•   Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, Grosse-Dunker G, Heisel I, Hornof F, Jeken J, Rebling NM, Ulrich C, Scheller B, Bohm M, Fliser D, Heine GH
  CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography. J Am Coll Cardiol. 2012 Oct 16;60(16):1512-20. doi: 10.1016/j.jacc.2012.07.019. Epub 2012 Sep 19.
•   Schafer PH, Parton A, Gandhi AK, Capone L, Adams M, Wu L, Bartlett JB, Loveland MA, Gilhar A, Cheung YF, Baillie GS, Houslay MD, Man HW, Muller GW, Stirling DI
  Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol. 2010 Feb;159(4):842-55. doi: 10.1111/j.1476-5381.2009.00559.x. Epub 2009 Dec 24.
•   Schlitt A, Heine GH, Blankenberg S, Espinola-Klein C, Dopheide JF, Bickel C, Lackner KJ, Iz M, Meyer J, Darius H, Rupprecht HJ
  CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost. 2004 Aug;92(2):419-24. doi: 10.1160/TH04-02-0095.
•   Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY
  Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J Thromb Haemost. 2011 May;9(5):1056-66. doi: 10.1111/j.1538-7836.2011.04244.x.
•   Singri P, West DP, Gordon KB
  Biologic therapy for psoriasis: the new therapeutic frontier. Arch Dermatol. 2002 May;138(5):657-63. doi: 10.1001/archderm.138.5.657.
•   Skrzeczynska J, Kobylarz K, Hartwich Z, Zembala M, Pryjma J
  CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand J Immunol. 2002 Jun;55(6):629-38. doi: 10.1046/j.1365-3083.2002.01092.x.
•   Tapp LD, Shantsila E, Wrigley BJ, Montoro-Garcia S, Lip GY
  TLR4 expression on monocyte subsets in myocardial infarction. J Intern Med. 2013 Mar;273(3):294-305. doi: 10.1111/joim.12011. Epub 2012 Dec 28.
•   Tapp LD, Shantsila E, Wrigley BJ, Pamukcu B, Lip GY
  The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J Thromb Haemost. 2012 Jul;10(7):1231-41. doi: 10.1111/j.1538-7836.2011.04603.x.
•   Wong KL, Tai JJ, Wong WC, Han H, Sem X, Yeap WH, Kourilsky P, Wong SC
  Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood. 2011 Aug 4;118(5):e16-31. doi: 10.1182/blood-2010-12-326355. Epub 2011 Jun 7.
•   Wrigley BJ, Shantsila E, Tapp LD, Lip GY
  CD14++CD16+ monocytes in patients with acute ischaemic heart failure. Eur J Clin Invest. 2013 Feb;43(2):121-30. doi: 10.1111/eci.12023. Epub 2012 Dec 14.
•   Zawada AM, Rogacev KS, Rotter B, Winter P, Marell RR, Fliser D, Heine GH
  SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood. 2011 Sep 22;118(12):e50-61. doi: 10.1182/blood-2011-01-326827. Epub 2011 Jul 29.
•   Zawada AM, Rogacev KS, Schirmer SH, Sester M, Bohm M, Fliser D, Heine GH
  Monocyte heterogeneity in human cardiovascular disease. Immunobiology. 2012 Dec;217(12):1273-84. doi: 10.1016/j.imbio.2012.07.001. Epub 2012 Jul 25.
•   Ziegler-Heitbrock HW
  Heterogeneity of human blood monocytes: the CD14+ CD16+ subpopulation. Immunol Today. 1996 Sep;17(9):424-8. doi: 10.1016/0167-5699(96)10029-3. No abstract available.
•   Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB
  Nomenclature of monocytes and dendritic cells in blood. Blood. 2010 Oct 21;116(16):e74-80. doi: 10.1182/blood-2010-02-258558. Epub 2010 Jul 13.

An Investigator Initiated Study of Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast

Details for clinical trial NCT03442088