Physical Activity — Metabolic Profile of Bone in Professional Athletes
Citation(s)
Allison RJ, Farooq A, Hamilton B, Close GL, Wilson MG No association between vitamin D deficiency and markers of bone health in athletes. Med Sci Sports Exerc. 2015 Apr;47(4):782-8. doi: 10.1249/MSS.0000000000000457.
Banfi G, Lombardi G, Colombini A, Lippi G Bone metabolism markers in sports medicine. Sports Med. 2010 Aug 1;40(8):697-714. doi: 10.2165/11533090-000000000-00000. Review.
Fang S, Deng Y, Gu P, Fan X MicroRNAs regulate bone development and regeneration. Int J Mol Sci. 2015 Apr 13;16(4):8227-53. doi: 10.3390/ijms16048227. Review.
Lombardi G, Lanteri P, Colombini A, Banfi G Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling. Clin Chem Lab Med. 2012 Feb 3;50(5):771-89. doi: 10.1515/cclm-2011-0614. Review.
Walsh MC, Choi Y Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond. Front Immunol. 2014 Oct 20;5:511. doi: 10.3389/fimmu.2014.00511. eCollection 2014. Review.
Study of the Metabolic Profile of Bone in Professional Athletes as a Function of the Kind of Physical Activity Performed
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
