Peripheral Perfusion — Topical Salve for Skin Oxygenation and Blood Flow
Citation(s)
Aboyans V, Ho E, Denenberg JO, Ho LA, Natarajan L, Criqui MH The association between elevated ankle systolic pressures and peripheral occlusive arterial disease in diabetic and nondiabetic subjects. J Vasc Surg. 2008 Nov;48(5):1197-203. doi: 10.1016/j.jvs.2008.06.005. Epub 2008 Aug 9.
Andrews KL, Dib MY, Shives TC, Hoskin TL, Liedl DA, Boon AJ Noninvasive arterial studies including transcutaneous oxygen pressure measurements with the limbs elevated or dependent to predict healing after partial foot amputation. Am J Phys Med Rehabil. 2013 May;92(5):385-92. doi: 10.1097/PHM.0b013e3182876a06.
Blake DF, Young DA, Brown LH Transcutaneous oximetry: normal values for the lower limb. Diving Hyperb Med. 2014 Sep;44(3):146-53. Retraction in: Diving Hyperb Med. 2016 Mar;46(1):54.
Browne AC, Sibbald RG The diabetic neuropathic ulcer: an overview. Ostomy Wound Manage. 1999 Jan;45(1A Suppl):6S-20S; quiz 21S-22S. Review.
Karanfilian RG, Lynch TG, Zirul VT, Padberg FT, Jamil Z, Hobson RW 2nd The value of laser Doppler velocimetry and transcutaneous oxygen tension determination in predicting healing of ischemic forefoot ulcerations and amputations in diabetic and nondiabetic patients. J Vasc Surg. 1986 Nov;4(5):511-6.
Kram HB, Appel PL, Shoemaker WC Multisensor transcutaneous oximetric mapping to predict below-knee amputation wound healing: use of a critical Po2. J Vasc Surg. 1989 Jun;9(6):796-800.
Mathieu D, Mani R A review of the clinical significance of tissue hypoxia measurements in lower extremity wound management. Int J Low Extrem Wounds. 2007 Dec;6(4):273-83. Review.
McDermott MM, Liu K, Guralnik JM, Martin GJ, Criqui MH, Greenland P Measurement of walking endurance and walking velocity with questionnaire: validation of the walking impairment questionnaire in men and women with peripheral arterial disease. J Vasc Surg. 1998 Dec;28(6):1072-81.
Reddy KK, Grossman L, Rogers GS Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. J Am Acad Dermatol. 2013 Apr;68(4):e127-e135. doi: 10.1016/j.jaad.2011.06.030. Epub 2011 Sep 3. Review.
Umscheid CA, Mitchell MD, Doshi JA, Agarwal R, Williams K, Brennan PJ Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect Control Hosp Epidemiol. 2011 Feb;32(2):101-14. doi: 10.1086/657912. Review.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
