NCT05307068 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Borilova Linhartova P, Danek Z, Deissova T, Hromcik F, Lipovy B, Szaraz D, Janos J, Fassmann A, Bartova J, Drizhal I, Izakovicova Holla L
Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis.
Clarke IJ, Tilbrook AJ, Galloway DB, Earl CR, Findlay JK, de Kretser DM
Inhibin in rams. J Reprod Fertil Suppl. 1991;43:163-70. No abstract available.
Geng Y, Li L, Wang X, He F, Zhou Y, Yang M, Xu Y
Interleukin-10 polymorphisms affect the key periodontal pathogens in Chinese periodontitis patients. Sci Rep. 2018 Jun 13;8(1):9068. doi: 10.1038/s41598-018-26236-4.
Orozco A, Gemmell E, Bickel M, Seymour GJ
Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. Oral Microbiol Immunol. 2006 Aug;21(4):256-60. doi: 10.1111/j.1399-302X.2006.
Pai B S, Pradeep AR
Correlations between Interleukin-33 and -1alpha Levels in Gingival Crevicular Fluid and Plasma in Patients with Chronic or Aggressive Periodontitis and Disease-free Subjects. Bull Tokyo Dent Coll. 2019 Dec 10;60(4):279-289. doi: 10.22
Park AY, Scott P
Il-12: keeping cell-mediated immunity alive. Scand J Immunol. 2001 Jun;53(6):529-32. doi: 10.1046/j.1365-3083.2001.00917.x.

Investigation of the Relationships and Clinical Parameters Between IL-10, IL-12 and IL-18 Levels in the Gingival Crevicular Fluid of Individuals With Grade B-C Stage III-IV Periodontitis

Details for clinical trial NCT05307068

Clinical trial NCT05307068 - References