NCT02124655 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

García-Caballero L, Quintas V, Prada-López I, Seoane J, Donos N, Tomás I
Chlorhexidine substantivity on salivary flora and plaque-like biofilm: an in situ model. PLoS One. 2013 Dec 27;8(12):e83522. doi: 10.1371/journal.pone.0083522. eCollection 2013.
Quintas V, Prada-López I, Prados-Frutos JC, Tomás I
In situ antimicrobial activity on oral biofilm: essential oils vs. 0.2 % chlorhexidine. Clin Oral Investig. 2015 Jan;19(1):97-107. doi: 10.1007/s00784-014-1224-3. Epub 2014 Apr 1.

Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth: a Randomised Clinical Trial.

Clinical trial NCT02124655 - References