Parkinson Disease — Deep Brain Stimulation-Induced Mania in Parkinson's Disease
Citation(s)
Accolla EA, Pollo C Mood Effects After Deep Brain Stimulation for Parkinson's Disease: An Update. Front Neurol. 2019 Jun 14;10:617. doi: 10.3389/fneur.2019.00617. eCollection 2019.
Benabid AL, Pollak P, Louveau A, Henry S, de Rougemont J Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol. 1987;50(1-6):344-6. doi: 10.1159/000100803.
Darby RR, Horn A, Cushman F, Fox MD Lesion network localization of criminal behavior. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):601-606. doi: 10.1073/pnas.1706587115. Epub 2017 Dec 18.
Darby RR, Laganiere S, Pascual-Leone A, Prasad S, Fox MD Finding the imposter: brain connectivity of lesions causing delusional misidentifications. Brain. 2017 Feb;140(2):497-507. doi: 10.1093/brain/aww288. Epub 2017 Jan 12.
Eklund A, Nichols TE, Knutsson H Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5. doi: 10.1073/pnas.1602413113. Epub 2016 Jun 28. Erratum In: Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4929.
Fox MD, Greicius M Clinical applications of resting state functional connectivity. Front Syst Neurosci. 2010 Jun 17;4:19. doi: 10.3389/fnsys.2010.00019. eCollection 2010.
Fox MD Mapping Symptoms to Brain Networks with the Human Connectome. N Engl J Med. 2018 Dec 6;379(23):2237-2245. doi: 10.1056/NEJMra1706158. No abstract available.
Mosley PE, Marsh R The psychiatric and neuropsychiatric symptoms after subthalamic stimulation for Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2015 Winter;27(1):19-26. doi: 10.1176/appi.neuropsych.14040069.
Mosley PE, Smith D, Coyne T, Silburn P, Breakspear M, Perry A The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease. Neuroimage Clin. 2018 Mar 13;18:996-1006. doi: 10.1016/j.nicl.2018.03.009. eCollection 2018.
Nutt JG, Wooten GF Clinical practice. Diagnosis and initial management of Parkinson's disease. N Engl J Med. 2005 Sep 8;353(10):1021-7. doi: 10.1056/NEJMcp043908. No abstract available.
Siegfried J, Lippitz B Bilateral chronic electrostimulation of ventroposterolateral pallidum: a new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery. 1994 Dec;35(6):1126-9; discussion 1129-30. doi: 10.1227/00006123-199412000-00016.
van den Heuvel MP, Hulshoff Pol HE Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34. doi: 10.1016/j.euroneuro.2010.03.008. Epub 2010 May 14.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.