Goodman AJ, Gress FG The endoscopic management of pain in chronic pancreatitis. Gastroenterol Res Pract. 2012;2012:860879. doi: 10.1155/2012/860879. Epub 2012 Mar 5.
Gress F, Schmitt C, Sherman S, Ciaccia D, Ikenberry S, Lehman G Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience. Am J Gastroenterol. 2001 Feb;96(2):409-16.
Gress F, Schmitt C, Sherman S, Ikenberry S, Lehman G A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain. Am J Gastroenterol. 1999 Apr;94(4):900-5.
Kaufman M, Singh G, Das S, Concha-Parra R, Erber J, Micames C, Gress F Efficacy of endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis for managing abdominal pain associated with chronic pancreatitis and pancreatic cancer. J Clin Gastroenterol. 2010 Feb;44(2):127-34. doi: 10.1097/MCG.0b013e3181bb854d. Review.
Kleykamp M Unemployment, earnings and enrollment among post 9/11 veterans. Soc Sci Res. 2013 May;42(3):836-51. doi: 10.1016/j.ssresearch.2012.12.017. Epub 2013 Jan 7.
Kozak LJ, Owings MF, Hall MJ National Hospital Discharge Survey: 2002 annual summary with detailed diagnosis and procedure data. Vital Health Stat 13. 2005 Mar;(158):1-199.
Sarles H Etiopathogenesis and definition of chronic pancreatitis. Dig Dis Sci. 1986 Sep;31(9 Suppl):91S-107S. Review.
Schneider A, Löhr JM, Singer MV The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease. J Gastroenterol. 2007 Feb;42(2):101-19. Epub 2007 Mar 12. Review.
Varadarajulu S, Eltoum I, Tamhane A, Eloubeidi MA Histopathologic correlates of noncalcific chronic pancreatitis by EUS: a prospective tissue characterization study. Gastrointest Endosc. 2007 Sep;66(3):501-9. Epub 2007 Jul 20.
Wilcox CM Tinkering with a tarnished technique: isn't it time to abandon celiac plexus blockade for the treatment of abdominal pain in chronic pancreatitis? Clin Gastroenterol Hepatol. 2012 Feb;10(2):106-8. doi: 10.1016/j.cgh.2011.10.039. Epub 2011 Nov 9.
Prospective Randomized Trial of EUS Guided Celiac Plexus Block for Chronic Pancreatitis
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
