Behrendorff N, Floetenmeyer M, Schwiening C, Thorn P Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice. Gastroenterology. 2010 Nov;139(5):1711-20, 1720.e1-5. doi: 10.1053/j.gastro.2010.07.051. Epub 2010 Aug 3.
Evander A, Lundquist I, Ihse I Influence of gastrointestinal hormones on the course of acute experimental pancreatitis. Hepatogastroenterology. 1982 Aug;29(4):161-6.
Everhart JE, Ruhl CE Burden of digestive diseases in the United States Part III: Liver, biliary tract, and pancreas. Gastroenterology. 2009 Apr;136(4):1134-44. doi: 10.1053/j.gastro.2009.02.038. Epub 2009 Feb 24. Review.
Freedman SD, Kern HF, Scheele GA Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis. Gastroenterology. 2001 Oct;121(4):950-7.
Goldenberg DE, Gordon SR, Gardner TB Management of acute pancreatitis. Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):687-94. doi: 10.1586/17474124.2014.907524. Epub 2014 Apr 25. Review.
Grady T, Saluja A, Kaiser A, Steer M Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis. Am J Physiol. 1996 Jul;271(1 Pt 1):G20-6.
Hegyi P, Maléth J, Venglovecz V, Rakonczay Z Jr Pancreatic ductal bicarbonate secretion: challenge of the acinar Acid load. Front Physiol. 2011 Jul 14;2:36. doi: 10.3389/fphys.2011.00036. eCollection 2011.
Hegyi P, Pandol S, Venglovecz V, Rakonczay Z Jr The acinar-ductal tango in the pathogenesis of acute pancreatitis. Gut. 2011 Apr;60(4):544-52. doi: 10.1136/gut.2010.218461. Epub 2010 Sep 28. Review.
Hegyi P, Petersen OH The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. Rev Physiol Biochem Pharmacol. 2013;165:1-30. doi: 10.1007/112_2013_14. Review.
Hegyi P, Rakonczay Z Jr The role of pancreatic ducts in the pathogenesis of acute pancreatitis. Pancreatology. 2015 Jul;15(4 Suppl):S13-7. doi: 10.1016/j.pan.2015.03.010. Epub 2015 Apr 7. Review.
Hegyi P, Rakonczay Z Insufficiency of electrolyte and fluid secretion by pancreatic ductal cells leads to increased patient risk for pancreatitis. Am J Gastroenterol. 2010 Sep;105(9):2119-20. doi: 10.1038/ajg.2010.191.
Levenick JM, Andrews CL, Purich ED, Gordon SR, Gardner TB A phase II trial of human secretin infusion for refractory type B pain in chronic pancreatitis. Pancreas. 2013 May;42(4):596-600. doi: 10.1097/MPA.0b013e318273f3ec. Erratum in: Pancreas. 2016 May-Jun;45(5):e23. Dosage error in article text.
Morimoto T, Noguchi Y, Sakai T, Shimbo T, Fukui T Acute pancreatitis and the role of histamine-2 receptor antagonists: a meta-analysis of randomized controlled trials of cimetidine. Eur J Gastroenterol Hepatol. 2002 Jun;14(6):679-86.
National Institutes of Health Opportunities and challenges in digestive diseases research: recommendations of the national commission on digestive diseases. March 2009. Retrieved January 29, 2017.
Niederau C, Ferrell LD, Grendell JH Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985 May;88(5 Pt 1):1192-204.
Prinz RA Mechanisms of acute pancreatitis. Vascular etiology. Int J Pancreatol. 1991 Summer;9:31-8. Review.
Rattner DW Experimental models of acute pancreatitis and their relevance to human disease. Scand J Gastroenterol Suppl. 1996;219:6-9.
Renner IG, Wisner JR Jr, Lavigne BC Partial restoration of pancreatic function by exogenous secretin in rats with ceruletide-induced acute pancreatitis. Dig Dis Sci. 1986 Mar;31(3):305-13.
Renner IG, Wisner JR Jr Ceruletide-induced acute pancreatitis in the dog and its amelioration by exogenous secretin. Int J Pancreatol. 1986 May;1(1):39-49.
Stevens T, Conwell DL, Zuccaro G Jr, Van Lente F, Lopez R, Purich E, Fein S A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis. Gastrointest Endosc. 2008 Mar;67(3):458-66. doi: 10.1016/j.gie.2007.07.028.
Vege SS, Atwal T, Bi Y, Chari ST, Clemens MA, Enders FT Pentoxifylline Treatment in Severe Acute Pancreatitis: A Pilot, Double-Blind, Placebo-Controlled, Randomized Trial. Gastroenterology. 2015 Aug;149(2):318-20.e3. doi: 10.1053/j.gastro.2015.04.019. Epub 2015 Jun 23.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.