Clinical trial NCT00597129 - References

Pancreatic Cancer — Safety and Efficacy Study of 90Y-hPAM4 at Different Doses

Citation(s)

•   Alisauskus R, Wong GY, Gold DV
  Initial studies of monoclonal antibody PAM4 targeting to xenografted orthotopic pancreatic cancer. Cancer Res. 1995 Dec 1;55(23 Suppl):5743s-5748s.
•   Cardillo TM, Blumenthal R, Ying Z, Gold DV
  Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer. Int J Cancer. 2002 Jan 20;97(3):386-92.
•   Cardillo TM, Ying Z, Gold DV
  Therapeutic advantage of (90)yttrium- versus (131)iodine-labeled PAM4 antibody in experimental pancreatic cancer. Clin Cancer Res. 2001 Oct;7(10):3186-92.
•   Gold DV, Alisauskas R, Sharkey RM
  Targeting of xenografted pancreatic cancer with a new monoclonal antibody, PAM4. Cancer Res. 1995 Mar 1;55(5):1105-10.
•   Gold DV, Cardillo T, Goldenberg DM, Sharkey RM
  Localization of pancreatic cancer with radiolabeled monoclonal antibody PAM4. Crit Rev Oncol Hematol. 2001 Jul-Aug;39(1-2):147-54.
•   Gold DV, Cardillo T, Vardi Y, Blumenthal R
  Radioimmunotherapy of experimental pancreatic cancer with 131I-labeled monoclonal antibody PAM4. Int J Cancer. 1997 May 16;71(4):660-7.
•   Gold DV, Karanjawala Z, Modrak DE, Goldenberg DM, Hruban RH
  PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma. Clin Cancer Res. 2007 Dec 15;13(24):7380-7.
•   Gold DV, Lew K, Maliniak R, Hernandez M, Cardillo T
  Characterization of monoclonal antibody PAM4 reactive with a pancreatic cancer mucin. Int J Cancer. 1994 Apr 15;57(2):204-10.
•   Gold DV, Modrak DE, Schutsky K, Cardillo TM
  Combined 90Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft. Int J Cancer. 2004 Apr 20;109(4):618-26.
•   Gold DV, Modrak DE, Ying Z, Cardillo TM, Sharkey RM, Goldenberg DM
  New MUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis. J Clin Oncol. 2006 Jan 10;24(2):252-8. Epub 2005 Dec 12.
•   Gold DV, Schutsky K, Modrak D, Cardillo TM
  Low-dose radioimmunotherapy ((90)Y-PAM4) combined with gemcitabine for the treatment of experimental pancreatic cancer. Clin Cancer Res. 2003 Sep 1;9(10 Pt 2):3929S-37S.
•   Mariani G, Molea N, Bacciardi D, Boggi U, Fornaciari G, Campani D, Salvadori PA, Giulianotti PC, Mosca F, Gold DV, et al
  Initial tumor targeting, biodistribution, and pharmacokinetic evaluation of the monoclonal antibody PAM4 in patients with pancreatic cancer. Cancer Res. 1995 Dec 1;55(23 Suppl):5911s-5915s.
•   Modrak DE, Cardillo TM, Newsome GA, Goldenberg DM, Gold DV
  Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer. Cancer Res. 2004 Nov 15;64(22):8405-10.
•   Modrak DE, Gold DV, Goldenberg DM, Blumenthal RD
  Colonic tumor CEA, CSAp and MUC-1 expression following radioimmunotherapy or chemotherapy. Tumour Biol. 2003 Jan-Feb;24(1):32-9.
•   Modrak DE, Gold DV, Goldenberg DM
  Sphingolipid targets in cancer therapy. Mol Cancer Ther. 2006 Feb;5(2):200-8. Review.
•   Modrak DE, Karacay H, Cardillo TM, Newsome G, Goldenberg DM, Gold DV
  Identification of a Mu-9 (anti-colon-specific antigen-p)-reactive peptide having homology to CA125 (MUC16). Int J Oncol. 2005 Jun;26(6):1591-6.
•   Reddy PK, Gold DV, Cardillo TM, Goldenberg DM, Li H, Burton JD
  Interferon-gamma upregulates MUC1 expression in haematopoietic and epithelial cancer cell lines, an effect associated with MUC1 mRNA induction. Eur J Cancer. 2003 Feb;39(3):397-404.

A Phase I, Dose-Escalating Study to Investigate the Safety, Tolerability, Pharmacokinetics and Dosimetry of a Single Dose of 90YHumanized PAM4 IgG in Patients With Locally Advanced/Metastatic Pancreatic Cancer

Details for clinical trial NCT00597129