Clinical trial NCT03854110 - References

Pancreatic Cancer, Adult — Trial to Evaluate Safety and Tolerability of GP-2250 in Combination With Gemcitabine

Citation(s)

•   Buchholz M, Majchrzak-Stiller B, Hahn S, Vangala D, Pfirrmann RW, Uhl W, Braumann C, Chromik AM
  Innovative substance 2250 as a highly promising anti-neoplastic agent in malignant pancreatic carcinoma - in vitro and in vivo. BMC Cancer. 2017 Mar 24;17(1):216. doi: 10.1186/s12885-017-3204-x.
•   Kim MS, Glassman D, Lankenau Ahumada A, et al
  Mechanisms and rational combinations with GP-2250, a novel oxathiazine derivative, in ovarian cancer. Poster presented at the AACR Annual Meeting 2023. April 14-19, 2023. Orange County Convention Center Orlando, Florida.
•   Majchrzak-Stiller B, Buchholz M, Peters I, Waschestjuk D, Strotmann J, Hohn P, Hahn S, Braumann C, Uhl W, Muller T, Mohler H
  GP-2250, a novel anticancer agent, inhibits the energy metabolism, activates AMP-Kinase and impairs the NF-kB pathway in pancreatic cancer cells. J Cell Mol Med. 2023 Jul;27(14):2082-2092. doi: 10.1111/jcmm.17825. Epub 2023 Jun 30.

Phase 1 Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of GP-2250 With Gemcitabine in Advanced Unresectable or Metastatic Pancreatic Adenocarcinoma Following Progression on 5-FU-based Chemotherapy

Details for clinical trial NCT03854110