NCT04230096 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Aihara N, Yamaguchi M, Kasai K
Low-energy irradiation stimulates formation of osteoclast-like cells via RANK expression in vitro. Lasers Med Sci. 2006 Apr;21(1):24-33. Epub 2006 Mar 28.
Hamdan AM
The relationship between patient, parent and clinician perceived need and normative orthodontic treatment need. Eur J Orthod. 2004 Jun;26(3):265-71.
Jones ML, Chan C
Pain in the early stages of orthodontic treatment. J Clin Orthod. 1992 May;26(5):311-3.
Jones ML, Richmond S
Initial tooth movement: force application and pain--a relationship? Am J Orthod. 1985 Aug;88(2):111-6.
Lim HM, Lew KK, Tay DK
A clinical investigation of the efficacy of low level laser therapy in reducing orthodontic postadjustment pain. Am J Orthod Dentofacial Orthop. 1995 Dec;108(6):614-22.
Qadri T, Miranda L, Tunér J, Gustafsson A
The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol. 2005 Jul;32(7):714-9.

Effect Of Low Level Laser Therapy on Tooth Movement,Gingival,Periodontal Tissue And Pain In Fixed Orthodontic Treatment

Clinical trial NCT04230096 - References