Borkovec TD, & Nau, S D. Credibility of analogue therapy rationales. Journal of Behavior Therapy and Experimental Psychiatry 1972;3:257-260.
Buhle J, Wager TD Does meditation training lead to enduring changes in the anticipation and experience of pain? Pain. 2010 Sep;150(3):382-3. doi: 10.1016/j.pain.2010.05.004. Epub 2010 May 23.
Cassidy EL, Atherton RJ, Robertson N, Walsh DA, Gillett R Mindfulness, functioning and catastrophizing after multidisciplinary pain management for chronic low back pain. Pain. 2012 Mar;153(3):644-50. doi: 10.1016/j.pain.2011.11.027. Epub 2012 Jan 11.
Coghill RC, Eisenach J Individual differences in pain sensitivity: implications for treatment decisions. Anesthesiology. 2003 Jun;98(6):1312-4.
Coghill RC, Mayer DJ, Price DD The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigation. Pain. 1993 Jun;53(3):295-309.
Coghill RC, McHaffie JG, Yen YF Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8538-42. Epub 2003 Jun 24. Erratum in: Proc Natl Acad Sci U S A. 2017 Nov 20;:. Yen, Ye-Fen [corrected to Yen, Yi-Fen].
Day MA, Smitherman A, Ward LC, Thorn BE An investigation of the associations between measures of mindfulness and pain catastrophizing. Clin J Pain. 2015 Mar;31(3):222-8. doi: 10.1097/AJP.0000000000000102.
Gard T, Hölzel BK, Sack AT, Hempel H, Lazar SW, Vaitl D, Ott U Pain attenuation through mindfulness is associated with decreased cognitive control and increased sensory processing in the brain. Cereb Cortex. 2012 Nov;22(11):2692-702. doi: 10.1093/cercor/bhr352. Epub 2011 Dec 15.
Garland EL, Gaylord SA, Palsson O, Faurot K, Douglas Mann J, Whitehead WE Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. J Behav Med. 2012 Dec;35(6):591-602. doi: 10.1007/s10865-011-9391-z. Epub 2011 Dec 8.
Grant JA, Rainville P Pain sensitivity and analgesic effects of mindful states in Zen meditators: a cross-sectional study. Psychosom Med. 2009 Jan;71(1):106-14. doi: 10.1097/PSY.0b013e31818f52ee. Epub 2008 Dec 10.
Kabat-Zinn J, Lipworth L, Burney R The clinical use of mindfulness meditation for the self-regulation of chronic pain. J Behav Med. 1985 Jun;8(2):163-90.
Kabat-Zinn J An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. Gen Hosp Psychiatry. 1982 Apr;4(1):33-47.
Kotov R, Bellman, S , & Watson, D. Multidimensional Iowa suggestibility scale: Brief Manual, 2007.
Koyama T, McHaffie JG, Laurienti PJ, Coghill RC The subjective experience of pain: where expectations become reality. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12950-5. Epub 2005 Sep 6.
Lutz A, Greischar LL, Perlman DM, Davidson RJ BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices. Neuroimage. 2009 Sep;47(3):1038-46. doi: 10.1016/j.neuroimage.2009.04.081. Epub 2009 May 5.
McNAir D, Loor, M , & Droppleman, L. Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service, 1971.
O'Grady KE The Absorption Scale: a factor-analytic assessment. Int J Clin Exp Hypn. 1980 Jul;28(3):281-8.
Perlman DM, Salomons TV, Davidson RJ, Lutz A Differential effects on pain intensity and unpleasantness of two meditation practices. Emotion. 2010 Feb;10(1):65-71. doi: 10.1037/a0018440.
Price DD, Bush FM, Long S, Harkins SW A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales. Pain. 1994 Feb;56(2):217-26.
Price DD, Harkins SW, Baker C Sensory-affective relationships among different types of clinical and experimental pain. Pain. 1987 Mar;28(3):297-307.
Prins B, Decuypere A, Van Damme S Effects of mindfulness and distraction on pain depend upon individual differences in pain catastrophizing: an experimental study. Eur J Pain. 2014 Oct;18(9):1307-15. doi: 10.1002/j.1532-2149.2014.491.x. Epub 2014 Mar 26.
Rhudy JL Respiration-induced hypoalgesia: additional evidence for pain modulation deficits in fibromyalgia? Pain. 2010 Apr;149(1):1-2. doi: 10.1016/j.pain.2010.01.004. Epub 2010 Feb 1.
Salkind MR Beck depression inventory in general practice. J R Coll Gen Pract. 1969 Nov;18(88):267-71.
Schütze R, Rees C, Preece M, Schütze M Low mindfulness predicts pain catastrophizing in a fear-avoidance model of chronic pain. Pain. 2010 Jan;148(1):120-7. doi: 10.1016/j.pain.2009.10.030. Epub 2009 Nov 26.
Watson D, Clark LA, Tellegen A Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988 Jun;54(6):1063-70.
White G Natural History and Antiquities of Selborne. London, England: Cassell and Company, 1908.
Worsley KJ, Evans AC, Marrett S, Neelin P A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab. 1992 Nov;12(6):900-18.
Yelle MD, Oshiro Y, Kraft RA, Coghill RC Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems. J Neurosci. 2009 Aug 19;29(33):10264-71. doi: 10.1523/JNEUROSCI.4648-08.2009.
Zeidan F, Emerson NM, Farris SR, Ray JN, Jung Y, McHaffie JG, Coghill RC Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced Analgesia. J Neurosci. 2015 Nov 18;35(46):15307-25. doi: 10.1523/JNEUROSCI.2542-15.2015.
Zeidan F, Gordon NS, Merchant J, Goolkasian P The effects of brief mindfulness meditation training on experimentally induced pain. J Pain. 2010 Mar;11(3):199-209. doi: 10.1016/j.jpain.2009.07.015. Epub 2009 Oct 22.
Zeidan F, Grant JA, Brown CA, McHaffie JG, Coghill RC Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett. 2012 Jun 29;520(2):165-73. doi: 10.1016/j.neulet.2012.03.082. Epub 2012 Apr 6. Review.
Zeidan F, Johnson SK, Diamond BJ, David Z, Goolkasian P Mindfulness meditation improves cognition: evidence of brief mental training. Conscious Cogn. 2010 Jun;19(2):597-605. doi: 10.1016/j.concog.2010.03.014. Epub 2010 Apr 3.
Zeidan F, Johnson SK, Gordon NS, Goolkasian P Effects of brief and sham mindfulness meditation on mood and cardiovascular variables. J Altern Complement Med. 2010 Aug;16(8):867-73. doi: 10.1089/acm.2009.0321.
Zeidan F The Neurobiology of Mindfulness Meditation. In: KW Brown, Creswell, J.D., & R.M., Ryan, editor. Handbook of Mindfulness Science: Theory, Research and Practice. New York, New York: The Guilford Press, 2015.
Identifying the Neurofunctional Connections Supporting Mindfulness Meditation Based Analgesia
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.