Bart-Knauer B, Friedl KE When will acupuncture become a first-line treatment for acute pain management? Mil Med. 2013 Aug;178(8):827-8. doi: 10.7205/MILMED-D-13-00119.
Busch V, Zeman F, Heckel A, Menne F, Ellrich J, Eichhammer P The effect of transcutaneous vagus nerve stimulation on pain perception--an experimental study. Brain Stimul. 2013 Mar;6(2):202-9. doi: 10.1016/j.brs.2012.04.006. Epub 2012 May 7.
Centers for Disease Control Prescription Painkiller Overdoses in the U.S. (2012). Prescription Painkiller Overdoses in the U.S.,4.
Cheng RS, Pomeranz BH Electroacupuncture analgesia is mediated by stereospecific opiate receptors and is reversed by antagonists of type I receptors. Life Sci. 1980 Feb 25;26(8):631-8.
Fang JQ, Fang JF, Liang Y, Du JY Electroacupuncture mediates extracellular signal-regulated kinase 1/2 pathways in the spinal cord of rats with inflammatory pain. BMC Complement Altern Med. 2014 Aug 4;14:285. doi: 10.1186/1472-6882-14-285.
Feng Y, Bai L, Ren Y, Wang H, Liu Z, Zhang W, Tian J Investigation of the large-scale functional brain networks modulated by acupuncture. Magn Reson Imaging. 2011 Sep;29(7):958-65. doi: 10.1016/j.mri.2011.04.009. Epub 2011 May 25.
Garcia AM State laws regulating prescribing of controlled substances: balancing the public health problems of chronic pain and prescription painkiller abuse and overdose. J Law Med Ethics. 2013 Mar;41 Suppl 1:42-5. doi: 10.1111/jlme.12037.
Haker E, Egekvist H, Bjerring P Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects. J Auton Nerv Syst. 2000 Feb 14;79(1):52-9.
Hommer DH Chinese scalp acupuncture relieves pain and restores function in complex regional pain syndrome. Mil Med. 2012 Oct;177(10):1231-4.
Ip, V (1999). The use of acupuncture for pain relief in a Chinese hospital clinic. Acupuncture In Medicine, 17(2), 101-109.
Kawakita K, Funakoshi M Suppression of the jaw-opening reflex by conditioning a-delta fiber stimulation and electroacupuncture in the rat. Exp Neurol. 1982 Nov;78(2):461-5.
King HC, Hickey AH, Connelly C Auricular acupuncture: a brief introduction for military providers. Mil Med. 2013 Aug;178(8):867-74. doi: 10.7205/MILMED-D-13-00075.
Mohler, Stanley R "Acupuncture Helps in Treating Medical Problems." Human Factors & Aviation Medicine. Flight Safety Foundation: September-October 2002, Vol. 49 No. 5
White P, Lewith G, Hopwood V, Prescott P The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomised, single-blind, cross-over pilot trial. Pain. 2003 Dec;106(3):401-9.
WHO The World Health Organization Viewpoint on Acupuncture. . Aug. 13, 2002.
Yoo YC, Oh JH, Kwon TD, Lee YK, Bai SJ Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study. Yonsei Med J. 2011 Nov;52(6):1016-21. doi: 10.3349/ymj.2011.52.6.1016.
Zhang AL, Parker SJ, Smit de V, Taylor DM, Xue CC Acupuncture and standard emergency department care for pain and/or nausea and its impact on emergency care delivery: a feasibility study. Acupunct Med. 2014 Jun;32(3):250-6. doi: 10.1136/acupmed-2013-010501. Epub 2014 Mar 7.
Zhang Y, Zhang RX, Zhang M, Shen XY, Li A, Xin J, Ren K, Berman BM, Tan M, Lao L Electroacupuncture inhibition of hyperalgesia in an inflammatory pain rat model: involvement of distinct spinal serotonin and norepinephrine receptor subtypes. Br J Anaesth. 2012 Aug;109(2):245-52. doi: 10.1093/bja/aes136. Epub 2012 May 23.
Auricular Acupuncture for the Acute Management of Pain in the Emergency Department
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.