Pain — Effective Analgesia During Routine Immunizations
Citation(s)
Berthoud HR, Lenard NR, Shin AC Food reward, hyperphagia, and obesity. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1266-77. doi: 10.1152/ajpregu.00028.2011. Epub 2011 Mar 16. Review.
Blass EM Milk-induced hypoalgesia in human newborns. Pediatrics. 1997 Jun;99(6):825-9.
Bo LK, Callaghan P Soothing pain-elicited distress in Chinese neonates. Pediatrics. 2000 Apr;105(4):E49.
Campos RG Soothing pain-elicited distress in infants with swaddling and pacifiers. Child Dev. 1989 Aug;60(4):781-92.
Field T, Goldson E Pacifying effects of nonnutritive sucking on term and preterm neonates during heelstick procedures. Pediatrics. 1984 Dec;74(6):1012-5.
Gray L, Watt L, Blass EM Skin-to-skin contact is analgesic in healthy newborns. Pediatrics. 2000 Jan;105(1):e14.
Harrison D, Bueno M, Yamada J, Adams-Webber T, Stevens B Analgesic effects of sweet-tasting solutions for infants: current state of equipoise. Pediatrics. 2010 Nov;126(5):894-902. doi: 10.1542/peds.2010-1593. Epub 2010 Oct 11. Review.
Howard CR, Howard FM, Weitzman ML Acetaminophen analgesia in neonatal circumcision: the effect on pain. Pediatrics. 1994 Apr;93(4):641-6.
Pickering, LK, ed RedBook: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009
Prasopkittikun T, Tilokskulchai F Management of pain from heel stick in neonates: an analysis of research conducted in Thailand. J Perinat Neonatal Nurs. 2003 Oct-Nov;17(4):304-12.
Reis EC Multiple scheduled injections contribute to missed opportunities to immunize during well care visits. Ambul Child Health 1997;3:172
Schade JG, Joyce BA, Gerkensmeyer J, Keck JF Comparison of three preverbal scales for postoperative pain assessment in a diverse pediatric sample. J Pain Symptom Manage. 1996 Dec;12(6):348-59.
Shah V, Taddio A, Ohlsson A Randomised controlled trial of paracetamol for heel prick pain in neonates. Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F209-11.
Stevens B, Yamada J, Ohlsson A Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001069. doi: 10.1002/14651858.CD001069.pub3. Review. Update in: Cochrane Database Syst Rev. 2013;1:CD001069.
Stice E, Yokum S, Burger KS, Epstein LH, Small DM Youth at risk for obesity show greater activation of striatal and somatosensory regions to food. J Neurosci. 2011 Mar 23;31(12):4360-6. doi: 10.1523/JNEUROSCI.6604-10.2011.
Taddio A, Ilersich AL, Ipp M, Kikuta A, Shah V; HELPinKIDS Team Physical interventions and injection techniques for reducing injection pain during routine childhood immunizations: systematic review of randomized controlled trials and quasi-randomized controlled trials. Clin Ther. 2009;31 Suppl 2:S48-76. doi: 10.1016/j.clinthera.2009.07.024. Review.
Taddio A, Shah V, Atenafu E, Katz J Influence of repeated painful procedures and sucrose analgesia on the development of hyperalgesia in newborn infants. Pain. 2009 Jul;144(1-2):43-8. doi: 10.1016/j.pain.2009.02.012. Epub 2009 Mar 28.
Tuck RH Coding and payment for immunizations. Pediatr Ann. 2006 Jul;35(7):507-12.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.