Clinical trial NCT03313869 - References

Oxidative Stress — A Nutrient Cocktail to Protect Against Physical Inactivity

Citation(s)

•   Adams GR, Caiozzo VJ, Baldwin KM
  Skeletal muscle unweighting: spaceflight and ground-based models. J Appl Physiol (1985). 2003 Dec;95(6):2185-201. Review.
•   Alibegovic AC, Højbjerre L, Sonne MP, van Hall G, Stallknecht B, Dela F, Vaag A
  Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes. 2009 Dec;58(12):2749-56. doi: 10.2337/db09-0369. Epub 2009 Aug 31.
•   Alibegovic AC, Sonne MP, Højbjerre L, Bork-Jensen J, Jacobsen S, Nilsson E, Faerch K, Hiscock N, Mortensen B, Friedrichsen M, Stallknecht B, Dela F, Vaag A
  Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E752-63. doi: 10.1152/ajpendo.00590.2009. Epub 2010 Aug 24.
•   Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF
  An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am J Clin Nutr. 2010 Apr;91(4):1044-59. doi: 10.3945/ajcn.2009.28822. Epub 2010 Feb 24.
•   Bergouignan A, Momken I, Lefai E, Antoun E, Schoeller DA, Platat C, Chery I, Zahariev A, Vidal H, Gabert L, Normand S, Freyssenet D, Laville M, Simon C, Blanc S
  Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations. Am J Clin Nutr. 2013 Sep;98(3):648-58. doi: 10.3945/ajcn.112.057075. Epub 2013 Jul 31.
•   Bergouignan A, Momken I, Schoeller DA, Normand S, Zahariev A, Lescure B, Simon C, Blanc S
  Regulation of energy balance during long-term physical inactivity induced by bed rest with and without exercise training. J Clin Endocrinol Metab. 2010 Mar;95(3):1045-53. doi: 10.1210/jc.2009-1005. Epub 2010 Jan 8.
•   Bergouignan A, Rudwill F, Simon C, Blanc S
  Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies. J Appl Physiol (1985). 2011 Oct;111(4):1201-10. doi: 10.1152/japplphysiol.00698.2011. Epub 2011 Aug 11. Review.
•   Bergouignan A, Trudel G, Simon C, Chopard A, Schoeller DA, Momken I, Votruba SB, Desage M, Burdge GC, Gauquelin-Koch G, Normand S, Blanc S
  Physical inactivity differentially alters dietary oleate and palmitate trafficking. Diabetes. 2009 Feb;58(2):367-76. doi: 10.2337/db08-0263. Epub 2008 Nov 18.
•   Biensø RS, Ringholm S, Kiilerich K, Aachmann-Andersen NJ, Krogh-Madsen R, Guerra B, Plomgaard P, van Hall G, Treebak JT, Saltin B, Lundby C, Calbet JA, Pilegaard H, Wojtaszewski JF
  GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012 May;61(5):1090-9. doi: 10.2337/db11-0884. Epub 2012 Mar 8.
•   Biolo G, Agostini F, Simunic B, Sturma M, Torelli L, Preiser JC, Deby-Dupont G, Magni P, Strollo F, di Prampero P, Guarnieri G, Mekjavic IB, Pisot R, Narici MV
  Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. Am J Clin Nutr. 2008 Oct;88(4):950-8.
•   Blanc S, Normand S, Ritz P, Pachiaudi C, Vico L, Gharib C, Gauquelin-Koch G
  Energy and water metabolism, body composition, and hormonal changes induced by 42 days of enforced inactivity and simulated weightlessness. J Clin Endocrinol Metab. 1998 Dec;83(12):4289-97.
•   Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM
  Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
•   Buehlmeier J, Frings-Meuthen P, Remer T, Maser-Gluth C, Stehle P, Biolo G, Heer M
  Alkaline salts to counteract bone resorption and protein wasting induced by high salt intake: results of a randomized controlled trial. J Clin Endocrinol Metab. 2012 Dec;97(12):4789-97. doi: 10.1210/jc.2012-2857. Epub 2012 Oct 1.
•   Cavanagh PR, Licata AA, Rice AJ
  Exercise and pharmacological countermeasures for bone loss during long-duration space flight. Gravit Space Biol Bull. 2005 Jun;18(2):39-58. Review.
•   Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA
  A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem. 2003 Mar 21;278(12):10297-303. Epub 2003 Jan 13.
•   Cree MG, Paddon-Jones D, Newcomer BR, Ronsen O, Aarsland A, Wolfe RR, Ferrando A
  Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides. Metabolism. 2010 May;59(5):703-10. doi: 10.1016/j.metabol.2009.09.014. Epub 2009 Nov 17.
•   Fitts RH, Riley DR, Widrick JJ
  Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol. 2001 Sep;204(Pt 18):3201-8. Review.
•   Gwag T, Park K, Park J, Lee JH, Nikawa T, Choi I
  Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation. J Physiol Pharmacol. 2015 Apr;66(2):273-83.
•   Hargens AR, Bhattacharya R, Schneider SM
  Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. Eur J Appl Physiol. 2013 Sep;113(9):2183-92. doi: 10.1007/s00421-012-2523-5. Epub 2012 Oct 19. Review.
•   Heilbronn L, Smith SR, Ravussin E
  Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S12-21. Review.
•   Hilder TL, Baer LA, Fuller PM, Fuller CA, Grindeland RE, Wade CE, Graves LM
  Insulin-independent pathways mediating glucose uptake in hindlimb-suspended skeletal muscle. J Appl Physiol (1985). 2005 Dec;99(6):2181-8. Epub 2005 Aug 11.
•   Hilder TL, Tou JC, Grindeland RE, Wade CE, Graves LM
  Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle. FEBS Lett. 2003 Oct 9;553(1-2):63-7.
•   Hirasaka K, Maeda T, Ikeda C, Haruna M, Kohno S, Abe T, Ochi A, Mukai R, Oarada M, Eshima-Kondo S, Ohno A, Okumura Y, Terao J, Nikawa T
  Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation. J Nutr Sci Vitaminol (Tokyo). 2013;59(4):317-24.
•   Hokayem M, Blond E, Vidal H, Lambert K, Meugnier E, Feillet-Coudray C, Coudray C, Pesenti S, Luyton C, Lambert-Porcheron S, Sauvinet V, Fedou C, Brun JF, Rieusset J, Bisbal C, Sultan A, Mercier J, Goudable J, Dupuy AM, Cristol JP, Laville M, Avignon A
  Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes Care. 2013 Jun;36(6):1454-61. doi: 10.2337/dc12-1652. Epub 2012 Dec 28.
•   Itani SI, Ruderman NB, Schmieder F, Boden G
  Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002 Jul;51(7):2005-11.
•   Kanazashi M, Tanaka M, Murakami S, Kondo H, Nagatomo F, Ishihara A, Roy RR, Fujino H
  Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb-unloaded rats by astaxanthin supplementation and intermittent loading. Exp Physiol. 2014 Aug;99(8):1065-77. doi: 10.1113/expphysiol.2014.079988. Epub 2014 Jun 6.
•   Kelley DE, Goodpaster BH, Storlien L
  Muscle triglyceride and insulin resistance. Annu Rev Nutr. 2002;22:325-46. Epub 2002 Jan 4. Review.
•   Kelley DE
  Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance. Ann N Y Acad Sci. 2002 Jun;967:135-45. Review.
•   Knudsen SH, Hansen LS, Pedersen M, Dejgaard T, Hansen J, Hall GV, Thomsen C, Solomon TP, Pedersen BK, Krogh-Madsen R
  Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men. J Appl Physiol (1985). 2012 Jul;113(1):7-15. doi: 10.1152/japplphysiol.00189.2011. Epub 2012 May 3. Erratum in: J Appl Physiol (1985). 2015 Feb 15;118(4):504.
•   Krebs JM, Schneider VS, Evans H, Kuo MC, LeBlanc AD
  Energy absorption, lean body mass, and total body fat changes during 5 weeks of continuous bed rest. Aviat Space Environ Med. 1990 Apr;61(4):314-8.
•   Krogh-Madsen R, Pedersen M, Solomon TP, Knudsen SH, Hansen LS, Karstoft K, Lehrskov-Schmidt L, Pedersen KK, Thomsen C, Holst JJ, Pedersen BK
  Normal physical activity obliterates the deleterious effects of a high-caloric intake. J Appl Physiol (1985). 2014 Feb 1;116(3):231-9. doi: 10.1152/japplphysiol.00155.2013. Epub 2013 Nov 7.
•   Lee SM, Moore AD, Everett ME, Stenger MB, Platts SH
  Aerobic exercise deconditioning and countermeasures during bed rest. Aviat Space Environ Med. 2010 Jan;81(1):52-63. Review.
•   Machida S, Booth FW
  Changes in signalling molecule levels in 10-day hindlimb immobilized rat muscles. Acta Physiol Scand. 2005 Feb;183(2):171-9.
•   Margaritis I, Rousseau AS, Marini JF, Chopard A
  Does antioxidant system adaptive response alleviate related oxidative damage with long term bed rest? Clin Biochem. 2009 Mar;42(4-5):371-9. doi: 10.1016/j.clinbiochem.2008.10.026. Epub 2008 Nov 24.
•   Mazzucco S, Agostini F, Biolo G
  Inactivity-mediated insulin resistance is associated with upregulated pro-inflammatory fatty acids in human cell membranes. Clin Nutr. 2010 Jun;29(3):386-90. doi: 10.1016/j.clnu.2009.09.006. Epub 2009 Oct 28.
•   Momken I, Stevens L, Bergouignan A, Desplanches D, Rudwill F, Chery I, Zahariev A, Zahn S, Stein TP, Sebedio JL, Pujos-Guillot E, Falempin M, Simon C, Coxam V, Andrianjafiniony T, Gauquelin-Koch G, Picquet F, Blanc S
  Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat. FASEB J. 2011 Oct;25(10):3646-60. doi: 10.1096/fj.10-177295. Epub 2011 Jun 29.
•   Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG
  Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S58-65. Review.
•   Morino K, Petersen KF, Shulman GI
  Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 2006 Dec;55 Suppl 2:S9-S15. Review.
•   Ngo Sock ET, Lê KA, Ith M, Kreis R, Boesch C, Tappy L
  Effects of a short-term overfeeding with fructose or glucose in healthy young males. Br J Nutr. 2010 Apr;103(7):939-43. doi: 10.1017/S0007114509992819. Epub 2009 Nov 24.
•   Novelle MG, Wahl D, Diéguez C, Bernier M, de Cabo R
  Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev. 2015 May;21:1-15. doi: 10.1016/j.arr.2015.01.002. Epub 2015 Jan 24. Review.
•   O'Keefe MP, Perez FR, Sloniger JA, Tischler ME, Henriksen EJ
  Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle. J Appl Physiol (1985). 2004 Jul;97(1):63-71. Epub 2004 Mar 5.
•   Ota N, Soga S, Haramizu S, Yokoi Y, Hase T, Murase T
  Tea catechins prevent contractile dysfunction in unloaded murine soleus muscle: a pilot study. Nutrition. 2011 Sep;27(9):955-9. doi: 10.1016/j.nut.2010.10.008. Epub 2011 Jun 8.
•   Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J
  From space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006). Eur J Appl Physiol. 2007 Sep;101(2):143-94. Epub 2007 Jul 28. Review.
•   Rector RS, Thyfault JP, Laye MJ, Morris RT, Borengasser SJ, Uptergrove GM, Chakravarthy MV, Booth FW, Ibdah JA
  Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J Physiol. 2008 Sep 1;586(17):4241-9. doi: 10.1113/jphysiol.2008.156745. Epub 2008 Jul 10.
•   Ritz P, Acheson KJ, Gachon P, Vico L, Bernard JJ, Alexandre C, Beaufrère B
  Energy and substrate metabolism during a 42-day bed-rest in a head-down tilt position in humans. Eur J Appl Physiol Occup Physiol. 1998 Sep;78(4):308-14.
•   Ruderman NB, Saha AK, Vavvas D, Witters LA
  Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 Jan;276(1 Pt 1):E1-E18. Review.
•   Rudwill F, Blanc S, Gauquelin-Koch G, Choukèr A, Heer M, Simon C, Bergouignan A
  Effects of different levels of physical inactivity on plasma visfatin in healthy normal-weight men. Appl Physiol Nutr Metab. 2013 Jun;38(6):689-93. doi: 10.1139/apnm-2012-0434. Epub 2013 Mar 8.
•   Sattar N, Scherbakova O, Ford I, O'Reilly DS, Stanley A, Forrest E, Macfarlane PW, Packard CJ, Cobbe SM, Shepherd J; west of Scotland coronary prevention study
  Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes. 2004 Nov;53(11):2855-60.
•   Savage DB, Petersen KF, Shulman GI
  Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007 Apr;87(2):507-20. Review.
•   Servais S, Letexier D, Favier R, Duchamp C, Desplanches D
  Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis? Free Radic Biol Med. 2007 Mar 1;42(5):627-35. Epub 2006 Dec 15.
•   Sigaudo D, Fortrat JO, Allevard AM, Maillet A, Cottet-Emard JM, Vouillarmet A, Hughson RL, Gauquelin-Koch G, Gharib C
  Changes in the sympathetic nervous system induced by 42 days of head-down bed rest. Am J Physiol. 1998 Jun;274(6 Pt 2):H1875-84.
•   Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
  Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr. 2011 Feb;93(2):402-12. doi: 10.3945/ajcn.110.005611. Epub 2010 Dec 15.
•   Stein TP, Blanc S
  Does protein supplementation prevent muscle disuse atrophy and loss of strength? Crit Rev Food Sci Nutr. 2011 Oct-Nov;51(9):828-34. doi: 10.1080/10408398.2010.482679. Review. Erratum in: Crit Rev Food Sci Nutr. 2012;52(10):957.
•   Stein TP, Leskiw MJ, Schluter MD, Hoyt RW, Lane HW, Gretebeck RE, LeBlanc AD
  Energy expenditure and balance during spaceflight on the space shuttle. Am J Physiol. 1999 Jun;276(6 Pt 2):R1739-48.
•   Stein TP, Schluter MD, Galante AT, Soteropoulos P, Ramirez M, Bigbee A, Grindeland RE, Wade CE
  Effect of hind limb muscle unloading on liver metabolism of rats. J Nutr Biochem. 2005 Jan;16(1):9-16.
•   Stein TP, Wade CE
  Metabolic consequences of muscle disuse atrophy. J Nutr. 2005 Jul;135(7):1824S-1828S. Review.
•   Stein TP
  Weight, muscle and bone loss during space flight: another perspective. Eur J Appl Physiol. 2013 Sep;113(9):2171-81. doi: 10.1007/s00421-012-2548-9. Epub 2012 Nov 29. Review.
•   Stettler R, Ith M, Acheson KJ, Décombaz J, Boesch C, Tappy L, Binnert C
  Interaction between dietary lipids and physical inactivity on insulin sensitivity and on intramyocellular lipids in healthy men. Diabetes Care. 2005 Jun;28(6):1404-9.
•   Tappy L, Lê KA, Tran C, Paquot N
  Fructose and metabolic diseases: new findings, new questions. Nutrition. 2010 Nov-Dec;26(11-12):1044-9. doi: 10.1016/j.nut.2010.02.014. Epub 2010 May 14. Review.
•   Trudel G, Payne M, Mädler B, Ramachandran N, Lecompte M, Wade C, Biolo G, Blanc S, Hughson R, Bear L, Uhthoff HK
  Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study. J Appl Physiol (1985). 2009 Aug;107(2):540-8. doi: 10.1152/japplphysiol.91530.2008. Epub 2009 May 28.
•   Unger RH
  Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology. 2003 Dec;144(12):5159-65. Epub 2003 Sep 4. Review.
•   van der Zijl NJ, Goossens GH, Moors CC, van Raalte DH, Muskiet MH, Pouwels PJ, Blaak EE, Diamant M
  Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on ß-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab. 2011 Feb;96(2):459-67. doi: 10.1210/jc.2010-1722. Epub 2010 Nov 17.
•   Vitadello M, Germinario E, Ravara B, Libera LD, Danieli-Betto D, Gorza L
  Curcumin counteracts loss of force and atrophy of hindlimb unloaded rat soleus by hampering neuronal nitric oxide synthase untethering from sarcolemma. J Physiol. 2014 Jun 15;592(12):2637-52. doi: 10.1113/jphysiol.2013.268672. Epub 2014 Apr 7.
•   Zwart SR, Hargens AR, Smith SM
  The ratio of animal protein intake to potassium intake is a predictor of bone resorption in space flight analogues and in ambulatory subjects. Am J Clin Nutr. 2004 Oct;80(4):1058-65.
•   Zwart SR, Pierson D, Mehta S, Gonda S, Smith SM
  Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronauts. J Bone Miner Res. 2010 May;25(5):1049-57. doi: 10.1359/jbmr.091041.

Effects of a Cocktail XXS-2A/Omega-3 on Insulin Sensitivity and Oxidative Stress During a 20-day Period of Physical Inactivity: a Controlled, Randomized Pilot Study on 20 Healthy Men

Details for clinical trial NCT03313869