Belanger C, Luu-The V, Dupont P, Tchernof A Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Horm Metab Res. 2002 Nov-Dec;34(11-12):737-45. doi: 10.1055/s-2002-38265.
Brasaemle DL, Dolios G, Shapiro L, Wang R Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem. 2004 Nov 5;279(45):46835-42. doi: 10.1074/jbc.M409340200. Epub 2004 Aug 27.
Cleland WH, Mendelson CR, Simpson ER Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes. Endocrinology. 1983 Dec;113(6):2155-60. doi: 10.1210/endo-113-6-2155.
D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem. 2005 Oct 28;280(43):35983-91. doi: 10.1074/jbc.M507339200. Epub 2005 Aug 17.
Ehrmann DA Polycystic ovary syndrome. N Engl J Med. 2005 Mar 24;352(12):1223-36. doi: 10.1056/NEJMra041536. No abstract available.
Elbers JM, Asscheman H, Seidell JC, Gooren LJ Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. Am J Physiol. 1999 Feb;276(2):E317-25. doi: 10.1152/ajpendo.1999.276.2.E317.
Elbers JM, Asscheman H, Seidell JC, Megens JA, Gooren LJ Long-term testosterone administration increases visceral fat in female to male transsexuals. J Clin Endocrinol Metab. 1997 Jul;82(7):2044-7. doi: 10.1210/jcem.82.7.4078.
Elia M, Livesey G Energy expenditure and fuel selection in biological systems: the theory and practice of calculations based on indirect calorimetry and tracer methods. World Rev Nutr Diet. 1992;70:68-131. doi: 10.1159/000421672. No abstract available.
Fabian MR, Sonenberg N, Filipowicz W Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351-79. doi: 10.1146/annurev-biochem-060308-103103.
Friso S, Choi SW, Dolnikowski GG, Selhub J A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem. 2002 Sep 1;74(17):4526-31. doi: 10.1021/ac020050h.
Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, Gustafsson JA, Dahlman-Wright K Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol. 2006 Jun;20(6):1287-99. doi: 10.1210/me.2006-0012. Epub 2006 Apr 20.
Grove KL, Fried SK, Greenberg AS, Xiao XQ, Clegg DJ A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. Int J Obes (Lond). 2010 Jun;34(6):989-1000. doi: 10.1038/ijo.2010.12. Epub 2010 Feb 16.
Guerre-Millo M, Leturque A, Girard J, Lavau M Increased insulin sensitivity and responsiveness of glucose metabolism in adipocytes from female versus male rats. J Clin Invest. 1985 Jul;76(1):109-16. doi: 10.1172/JCI111932.
Guo K, Mogen J, Struzzi S, Zhang Y Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1339-47. doi: 10.1152/ajpregu.90691.2008. Epub 2009 Feb 4.
Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4854-8. doi: 10.1073/pnas.91.11.4854.
Khor VK, Tong MH, Qian Y, Song WC Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse. Endocrinology. 2008 Nov;149(11):5440-8. doi: 10.1210/en.2008-0271. Epub 2008 Jul 31.
Lavau M, Susini C, Knittle J, Blanchet-Hirst S, Greenwood MR A reliable photomicrographic method to determining fat cell size and number: application to dietary obesity. Proc Soc Exp Biol Med. 1977 Nov;156(2):251-6. doi: 10.3181/00379727-156-39916. No abstract available.
Lavebratt C, Almgren M, Ekstrom TJ Epigenetic regulation in obesity. Int J Obes (Lond). 2012 Jun;36(6):757-65. doi: 10.1038/ijo.2011.178. Epub 2011 Sep 13.
Livingstone MB, Black AE Markers of the validity of reported energy intake. J Nutr. 2003 Mar;133 Suppl 3:895S-920S. doi: 10.1093/jn/133.3.895S.
Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond). 2008 Jun;32(6):949-58. doi: 10.1038/ijo.2008.25. Epub 2008 Mar 11.
Macotela Y, Boucher J, Tran TT, Kahn CR Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes. 2009 Apr;58(4):803-12. doi: 10.2337/db08-1054. Epub 2009 Jan 9.
Marin P, Krotkiewski M, Bjorntorp P Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues. Eur J Med. 1992 Oct;1(6):329-36.
Perrot-Sinal TS Do these genes make me look fat? Endocrinology. 2009 Mar;150(3):1075-7. doi: 10.1210/en.2008-1586. No abstract available.
Riant E, Waget A, Cogo H, Arnal JF, Burcelin R, Gourdy P Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology. 2009 May;150(5):2109-17. doi: 10.1210/en.2008-0971. Epub 2009 Jan 22.
Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology. 2009 May;150(5):2161-8. doi: 10.1210/en.2008-1405. Epub 2009 Jan 29.
Schoeller DA, Racette SB A review of field techniques for the assessment of energy expenditure. J Nutr. 1990 Nov;120 Suppl 11(11 Suppl):1492-5. doi: 10.1093/jn/120.suppl_11.1492.
Shi H, Seeley RJ, Clegg DJ Sexual differences in the control of energy homeostasis. Front Neuroendocrinol. 2009 Aug;30(3):396-404. doi: 10.1016/j.yfrne.2009.03.004. Epub 2009 Mar 31.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.