Clinical trial NCT04338867 - References

ICPFS Evaluated by Two Blinded and Independent Radio-oncologist With MRI — Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients

Citation(s)

•   Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr
  Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004 May 22;363(9422):1665-72.
•   Arrieta O, Blake M, de la Mata-Moya MD, Corona F, Turcott J, Orta D, Alexander-Alatorre J, Gallardo-Rincón D
  Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer. Radiother Oncol. 2014 May;111(2):311-5. doi: 10.1016/j.radonc.2014.01.021. Epub 2014 May 14.
•   Barker HE, Paget JT, Khan AA, Harrington KJ
  The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015 Jul;15(7):409-25. doi: 10.1038/nrc3958. Review. Erratum in: Nat Rev Cancer. 2015 Aug;15(8):509.
•   Berghoff AS, Preusser M
  The inflammatory microenvironment in brain metastases: potential treatment target? Chin Clin Oncol. 2015 Jun;4(2):21. doi: 10.3978/j.issn.2304-3865.2015.06.03. Review.
•   Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epu
•   Choudhari SK, Chaudhary M, Bagde S, Gadbail AR, Joshi V
  Nitric oxide and cancer: a review. World J Surg Oncol. 2013 May 30;11:118. doi: 10.1186/1477-7819-11-118. Review.
•   Gondi V, Pugh SL, Tome WA, Caine C, Corn B, Kanner A, Rowley H, Kundapur V, DeNittis A, Greenspoon JN, Konski AA, Bauman GS, Shah S, Shi W, Wendland M, Kachnic L, Mehta MP
  Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol. 2014 Dec 1;32(34):3810-6. doi: 10.1200/JCO.2014.57.2909. Epub 2014 Oct 27.
•   Huber SM, Butz L, Stegen B, Klumpp D, Braun N, Ruth P, Eckert F
  Ionizing radiation, ion transports, and radioresistance of cancer cells. Front Physiol. 2013 Aug 14;4:212. doi: 10.3389/fphys.2013.00212. eCollection 2013.
•   Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S
  Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. J Biol Chem. 1998 Jun 12;273(24):15257-62.
•   Moeller BJ, Cao Y, Li CY, Dewhirst MW
  Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell. 2004 May;5(5):429-41.
•   Moeller BJ, Cao Y, Vujaskovic Z, Li CY, Haroon ZA, Dewhirst MW
  The relationship between hypoxia and angiogenesis. Semin Radiat Oncol. 2004 Jul;14(3):215-21. Review.
•   Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW
  Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 2005 Aug;8(2):99-110.
•   Reinmuth N, Meyer A, Hartwigsen D, Schaeper C, Huebner G, Skock-Lober R, Bier A, Gerecke U, Held CP, Reck M
  Randomized, double-blind phase II study to compare nitroglycerin plus oral vinorelbine plus cisplatin with oral vinorelbine plus cisplatin alone in patients with stage IIIB/IV non-small cell lung cancer (NSCLC). Lung Cancer. 2014 Mar;83(3):363-8. doi: 10.1016/j.lungcan.2014.01.001. Epub 2014 Jan 8.
•   Rojas-Puentes LL, Gonzalez-Pinedo M, Crismatt A, Ortega-Gomez A, Gamboa-Vignolle C, Nuñez-Gomez R, Dorantes-Gallareta Y, Arce-Salinas C, Arrieta O
  Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases. Radiat Oncol. 2013 Sep 8;8:209. doi: 10.1186/1748-717X-8-209.
•   Tian J, Luo Y, Xiang J, Tang J
  Combined treatment for non-small cell lung cancer and breast cancer patients with brain metastases with whole brain radiotherapy and temozolomide: a systematic review and meta-analysis. J Neurooncol. 2017 Nov;135(2):217-227. doi: 10.1007/s11060-017-2572-z. Epub 2017 Jul 19. Review.

Nitroglycerin Plus Whole Intracranial Radiotherapy for Brain Metastases in Non-small Cell Lung Cancer Patients: a Phase II Open Randomized Clinical Trial

Details for clinical trial NCT04338867