NCT00225381 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Breen PH, Isserles SA, Harrison BA, Roizen MF
Simple computer measurement of pulmonary VCO2 per breath. J Appl Physiol (1985). 1992 May;72(5):2029-35.
Breen PH, Isserles SA, Taitelman UZ
Non-steady state monitoring by respiratory gas exchange. J Clin Monit Comput. 2000;16(5-6):351-60. Review.
Breen PH, Mazumdar B, Skinner SC
Capnometer transport delay: measurement and clinical implications. Anesth Analg. 1994 Mar;78(3):584-6.
Breen PH, Serina ER, Barker SJ
Measurement of pulmonary CO2 elimination must exclude inspired CO2 measured at the capnometer sampling site. J Clin Monit. 1996 May;12(3):231-6.
Breen PH, Serina ER
Bymixer provides on-line calibration of measurement of CO2 volume exhaled per breath. Ann Biomed Eng. 1997 Jan-Feb;25(1):164-71.
Breen PH
Importance of temperature and humidity in the measurement of pulmonary oxygen uptake per breath during anesthesia. Ann Biomed Eng. 2000 Sep;28(9):1159-64.
Isserles SA, Breen PH
Can changes in end-tidal PCO2 measure changes in cardiac output? Anesth Analg. 1991 Dec;73(6):808-14.
Rosenbaum A, Breen PH
Importance and interpretation of fast-response airway hygrometry during ventilation of anesthetized patients. J Clin Monit Comput. 2007 Jun;21(3):137-46. Epub 2007 Mar 16.
Rosenbaum A, Breen PH
Novel, adjustable, clinical bymixer measures mixed expired gas concentrations in anesthesia circle circuit. Anesth Analg. 2003 Nov;97(5):1414-20.
Rosenbaum A, Kirby C, Breen PH
Measurement of oxygen uptake and carbon dioxide elimination using the bymixer: validation in a metabolic lung simulator. Anesthesiology. 2004 Jun;100(6):1427-37.
Rosenbaum A, Kirby C, Breen PH
New metabolic lung simulator: development, description, and validation. J Clin Monit Comput. 2007 Apr;21(2):71-82. Epub 2007 Mar 1.

Gas Kinetics and Metabolism in Anesthesia During Non Steady State

Details for clinical trial NCT00225381

Clinical trial NCT00225381 - References