Lower Limb Amputation Below Knee (Injury) — Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
Citation(s)
Agrawal V, Gailey RS, Gaunaurd IA, O'Toole C, Finnieston A, Tolchin R Comparison of four different categories of prosthetic feet during ramp ambulation in unilateral transtibial amputees. Prosthet Orthot Int. 2015 Oct;39(5):380-9. doi: 10.1177/0309364614536762. Epub 2014 Jun 12.
Boone DA, Coleman KL Use of the Prosthesis Evaluation Questionnaire (PEQ). JPO: Journal of Prosthetics and Orthotics. 2006;18(6).
Borg GA Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.
Cho YS, Jang SH, Cho JS, Kim MJ, Lee HD, Lee SY, Moon SB Evaluation of Validity and Reliability of Inertial Measurement Unit-Based Gait Analysis Systems. Ann Rehabil Med. 2018 Dec;42(6):872-883. doi: 10.5535/arm.2018.42.6.872. Epub 2018 Dec 28.
Hart SG, Staveland LE Development of NASA-TLX (Task Load Index): Results of Empirical and Theoretical Research. In: Hancock PA, Meshkati N, editors. Advances in Psychology. 52: North-Holland; 1988. p. 139-83.
Howard CL, Wallace C, Perry B, Stokic DS Comparison of mobility and user satisfaction between a microprocessor knee and a standard prosthetic knee: a summary of seven single-subject trials. Int J Rehabil Res. 2018 Mar;41(1):63-73. doi: 10.1097/MRR.0000000000000267.
Hunter SW, Frengopoulos C, Holmes J, Viana R, Payne MW Determining Reliability of a Dual-Task Functional Mobility Protocol for Individuals With Lower Extremity Amputation. Arch Phys Med Rehabil. 2018 Apr;99(4):707-712. doi: 10.1016/j.apmr.2017.12.008. Epub 2018 Jan 6.
Kong XZ, Liu Z, Huang L, Wang X, Yang Z, Zhou G, Zhen Z, Liu J Mapping Individual Brain Networks Using Statistical Similarity in Regional Morphology from MRI. PLoS One. 2015 Nov 4;10(11):e0141840. doi: 10.1371/journal.pone.0141840. eCollection 2015.
Lamb PF, Stockl M On the use of continuous relative phase: Review of current approaches and outline for a new standard. Clin Biomech (Bristol, Avon). 2014 May;29(5):484-93. doi: 10.1016/j.clinbiomech.2014.03.008. Epub 2014 Mar 26.
Lee KA, Hicks G, Nino-Murcia G Validity and reliability of a scale to assess fatigue. Psychiatry Res. 1991 Mar;36(3):291-8. doi: 10.1016/0165-1781(91)90027-m.
Mahon CE, Hendershot BD Biomechanical accommodation to walking with an ankle-foot prosthesis: An exploratory analysis of novice users with transtibial limb loss within the first year of ambulation. Prosthet Orthot Int. 2022 Oct 1;46(5):452-458. doi: 10.1097/PXR.0000000000000124. Epub 2022 Mar 25.
Ozer S, Young J, Champ C, Burke M A systematic review of the diagnostic test accuracy of brief cognitive tests to detect amnestic mild cognitive impairment. Int J Geriatr Psychiatry. 2016 Nov;31(11):1139-1150. doi: 10.1002/gps.4444. Epub 2016 Feb 18.
Peterson SM, Ferris DP Group-level cortical and muscular connectivity during perturbations to walking and standing balance. Neuroimage. 2019 Sep;198:93-103. doi: 10.1016/j.neuroimage.2019.05.038. Epub 2019 May 18.
Rogge AK, Roder B, Zech A, Hotting K Exercise-induced neuroplasticity: Balance training increases cortical thickness in visual and vestibular cortical regions. Neuroimage. 2018 Oct 1;179:471-479. doi: 10.1016/j.neuroimage.2018.06.065. Epub 2018 Jun 26.
Russell Esposito E, Aldridge Whitehead JM, Wilken JM Step-to-step transition work during level and inclined walking using passive and powered ankle-foot prostheses. Prosthet Orthot Int. 2016 Jun;40(3):311-9. doi: 10.1177/0309364614564021. Epub 2015 Jan 27.
Schmalz T, Blumentritt S, Marx B Biomechanical analysis of stair ambulation in lower limb amputees. Gait Posture. 2007 Feb;25(2):267-78. doi: 10.1016/j.gaitpost.2006.04.008. Epub 2006 May 24.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
