Clinical trial NCT03887624 - References

Depressive Disorder, Treatment-Resistant — Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.

Citation(s)

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•   Cui Y, Hu S, Hu H
  Lateral Habenular Burst Firing as a Target of the Rapid Antidepressant Effects of Ketamine. Trends Neurosci. 2019 Mar;42(3):179-191. doi: 10.1016/j.tins.2018.12.002. Review.
•   Cui Y, Yang Y, Ni Z, Dong Y, Cai G, Foncelle A, Ma S, Sang K, Tang S, Li Y, Shen Y, Berry H, Wu S, Hu H
  Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature. 2018 Feb 14;554(7692):323-327. doi: 10.1038/nature25752.
•   Sackeim HA
  The definition and meaning of treatment-resistant depression. J Clin Psychiatry. 2001;62 Suppl 16:10-7. Review.
•   Sarkisova KY, Kuznetsova GD, Kulikov MA, van Luijtelaar G
  Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. Epilepsia. 2010 Jan;51(1):146-60. doi: 10.1111/j.1528-1167.2009.02260.x. Epub 2009 Aug 8.
•   Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H
  Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 2018 Feb 14;554(7692):317-322. doi: 10.1038/nature25509.

A Randomized, Parallel-group，Placebo-controlled, Double-blind Clinical Trial to Evaluate the Efficacy and Safety of Ethosuximide in Chinese Patients With Treatment-Resistant Depression.

Details for clinical trial NCT03887624