NCT03399422 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Almpani K, Kantarci A
Nonsurgical Methods for the Acceleration of the Orthodontic Tooth Movement. Front Oral Biol. 2016;18:80-91. doi: 10.1159/000382048. Epub 2015 Nov 24. Review.
Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G
Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009 Feb;27(1):63-9. doi: 10.1080/08977190802636713.
Güleç A, Bakkalbasi BÇ, Cumbul A, Uslu Ü, Alev B, Yarat A
Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study. Am J Orthod Dentofacial Orthop. 2017 Jan;151(1):92-104. doi: 10.1016/j.ajodo.2016.05.016.
Naik B, Karunakar P, Jayadev M, Marshal VR
Role of Platelet rich fibrin in wound healing: A critical review. J Conserv Dent. 2013 Jul;16(4):284-93. doi: 10.4103/0972-0707.114344.
Rosvall MD, Fields HW, Ziuchkovski J, Rosenstiel SF, Johnston WM
Attractiveness, acceptability, and value of orthodontic appliances. Am J Orthod Dentofacial Orthop. 2009 Mar;135(3):276.e1-12; discussion 276-7. doi: 10.1016/j.ajodo.2008.09.020.
Ziegler P, Ingervall B
A clinical study of maxillary canine retraction with a retraction spring and with sliding mechanics. Am J Orthod Dentofacial Orthop. 1989 Feb;95(2):99-106.

Evaluation the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) in Upper Canine Retraction and the Levels of Acceptance and Discomfort

Clinical trial NCT03399422 - References